The Impact of Food Specific IgG Antibodies on Migraine and Its Comorbidities

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunity, Inflammation and Disease Pub Date : 2024-11-17 DOI:10.1002/iid3.70056

Zhi-Ming Zhao, Mei-Mei Yang, Xian-Shu Zhao, Fu-Jun Wan, Bao-Li Ning, Li-Ming Zhang, Jun Fu

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Abstract

Objective

To investigate the differences in headache and comorbidity symptoms between migraine patients with negative and positive food specific IgG antibodies, and explore the correlation between these symptoms with food specific IgG antibodies.

Methods

A total of 129 migraine patients were enrolled. Seven questionnaires were used to gather information regarding the symptoms of migraine, gastrointestinal, depression, anxiety, and sleep. Serum specific IgG antibodies against 14 kinds of food were detected using enzyme-linked immunosorbent assays.

Results

Patients with migraine diagnosis who had positive food specific IgG antibodies had significantly worse headaches, gastrointestinal and anxiety symptoms, compared to the patients with negative IgG antibodies. Patients with more IgG positive foods and higher total positive IgG concentration generally had worse migraine conditions, anxiety, depression, and gastrointestinal symptoms.

Conclusion

The effect of food specific IgG antibodies on severity of migraine and its comorbidities were antibody-quantity and IgG-concentration dependent. Future studies are warranted to explore the mechanism underlying such relationship.

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食物特异性 IgG 抗体对偏头痛及其并发症的影响

目的研究食物特异性 IgG 抗体阴性和阳性偏头痛患者在头痛和合并症症状方面的差异，并探讨这些症状与食物特异性 IgG 抗体之间的相关性：方法：共招募了 129 名偏头痛患者。方法：共招募了 129 名偏头痛患者，使用 7 份问卷调查偏头痛、胃肠道、抑郁、焦虑和睡眠症状。使用酶联免疫吸附试验检测血清中针对 14 种食物的特异性 IgG 抗体：结果：与 IgG 抗体阴性的患者相比，食物特异性 IgG 抗体阳性的偏头痛患者的头痛、胃肠道和焦虑症状明显加重。IgG阳性食物越多、IgG总阳性浓度越高的患者，偏头痛症状、焦虑、抑郁和胃肠道症状普遍越严重：结论：食物特异性 IgG 抗体对偏头痛严重程度及其合并症的影响与抗体数量和 IgG 浓度有关。未来的研究需要探索这种关系的内在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity, Inflammation and Disease Medicine-Immunology and Allergy

CiteScore

3.60

自引率

0.00%

发文量

146

审稿时长

8 weeks

期刊介绍： Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including: • cellular and molecular immunology • clinical immunology • allergy • immunochemistry • immunogenetics • immune signalling • immune development • imaging • mathematical modelling • autoimmunity • transplantation immunology • cancer immunology