Lp(a) and high-sensitivity C-reactive protein are predictive biomarkers for coronary heart disease in Chinese patients with type 2 diabetes mellitus.

IF 3.4 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Heliyon Pub Date : 2024-11-01 eCollection Date: 2024-11-15 DOI:10.1016/j.heliyon.2024.e40074

Qinghan Meng, Haina Ma, Nannan Tian, Zheng Wang, Liwen Cai, Yuqi Zhang, Qian Wang, Ruiwang Zhen, Jinwen Zhao, Menghan Wang, Xinqi Wang, Haifei Liu, Yuan Liu, Xinyu Wang, Li Wang

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Abstract

Objective: Type 2 diabetes (T2DM) is a significant risk factor for coronary heart disease (CHD). This study aimed to assess the variations in biomarkers associated with CHD in T2DM patients across different age groups in the Han Chinese population.

Methods: A strict selection process was employed, involving three groups: a control group (n = 300) with no medical history, a new-onset T2DM group (n = 300), and a new-onset T2DM + CHD group (n = 300). Participants in each group were further categorized based on age: Group 1 (<60 years), Group 2 (60-75 years), and Group 3 (>75 years). Fasting glucose, hemoglobin A1c (HbA1c), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), ApoB/ApoA1 ratio, lipoprotein(a) [Lp(a)], high-sensitivity C-reactive protein (hsCRP), and homocysteine (HCY) levels were analyzed in all groups.

Results: Both T2DM and T2DM + CHD groups exhibited elevated levels of TG, TC, LDL-C, ApoB, ApoB/ApoA1, Lp(a), hsCRP, and HCY, alongside decreased levels of HDL-C and ApoA1 in comparison to the control group. Notably, when comparing the T2DM to the T2DM + CHD groups, significant increases were noted in ApoB, Lp(a), and hsCRP levels in the T2DM + CHD group, whereas other biomarkers did not show significant differences. Across all age groups, the patterns remained consistent, with the T2DM and T2DM + CHD groups showing elevated levels of TG, TC, LDL-C, ApoB, ApoB/ApoA1, Lp(a), hsCRP, and HCY, and decreased levels of HDL-C and ApoA1 compared to their respective age-matched control groups. Furthermore, within each age category, significant increases in ApoB, Lp(a), and hsCRP were specifically observed with advancing age in the T2DM + CHD group, with Lp(a) and hsCRP levels showing particularly notable elevations, underscoring their potential as significant indicators of CHD risk in the T2DM population.

Conclusion: Lp(a) and hsCRP may serve as valuable risk biomarkers for the development of CHD in T2DM patients. Understanding the variations in these biomarkers across different age groups can assist in risk assessment and the development of personalized management strategies for CHD in T2DM patients.

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脂蛋白（a）和高敏 C 反应蛋白是中国 2 型糖尿病患者冠心病的预测性生物标志物。

目的：2型糖尿病（T2DM）是冠心病（CHD）的重要危险因素。本研究旨在评估中国汉族人群中不同年龄组 T2DM 患者与冠心病相关的生物标志物的变化：研究采用严格的筛选程序，分为三组：无病史对照组（300 人）、新发 T2DM 组（300 人）和新发 T2DM + CHD 组（300 人）。每组参与者根据年龄进一步分类：第一组（75 岁）。空腹血糖、血红蛋白 A1c (HbA1c)、甘油三酯 (TG)、总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL-C)、高密度脂蛋白胆固醇 (HDL-C)、对各组的载脂蛋白 A1（ApoA1）、载脂蛋白 B（ApoB）、ApoB/ApoA1 比值、脂蛋白（a）[Lp（a）]、高敏 C 反应蛋白（hsCRP）和同型半胱氨酸（HCY）水平进行了分析。结果与对照组相比，T2DM 组和 T2DM + CHD 组的 TG、TC、LDL-C、载脂蛋白 B、载脂蛋白 B/载脂蛋白 A1、Lp(a)、hsCRP 和 HCY 水平均升高，而 HDL-C 和载脂蛋白 A1 水平降低。值得注意的是，当将 T2DM 组与 T2DM + 冠心病组进行比较时，发现 T2DM + 冠心病组的载脂蛋白B、脂蛋白（a）和 hsCRP 水平显著升高，而其他生物标志物则无显著差异。与各自年龄匹配的对照组相比，T2DM 组和 T2DM + CHD 组的 TG、TC、LDL-C、载脂蛋白 B、载脂蛋白 B/载脂蛋白 A1、脂蛋白（a）、hsCRP 和 HCY 水平升高，而 HDL-C 和载脂蛋白 A1 水平下降。此外，在每个年龄组中，随着年龄的增长，T2DM + 冠心病组中的载脂蛋白B、脂蛋白（a）和hsCRP都出现了显著升高，其中脂蛋白（a）和hsCRP水平的升高尤为明显，这表明它们有可能成为T2DM人群中冠心病风险的重要指标：结论：脂蛋白（a）和 hsCRP 可作为 T2DM 患者罹患冠心病的重要风险生物标志物。了解这些生物标志物在不同年龄段的变化有助于对 T2DM 患者进行风险评估和制定个性化的冠心病管理策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heliyon MULTIDISCIPLINARY SCIENCES-

CiteScore

4.50

自引率

2.50%

发文量

2793

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