Low Prognostic Nutritional Index (PNI) Level is Associated with an Increased Risk of Neonatal Respiratory Distress Syndrome in Preterm Infants with Different Gestational Ages: A Retrospective Study.

IF 2.1 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of General Medicine Pub Date : 2024-11-12 eCollection Date: 2024-01-01 DOI:10.2147/IJGM.S486224

Liudan Huang, Xuexin Chen, Yuhua Zhang

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引用次数: 0

Abstract

Background: Neonatal respiratory distress syndrome (NRDS) is common in preterm infants. Prognostic nutritional index (PNI)((albumin (g/L)+(5×total lymphocyte count (10⁹/L)) is a comprehensive indicator of nutritional and immune levels, and associated with several diseases. The relationship between PNI and the risk of NRDS in newborns of different gestational ages remains unclear.

Methods: A total of 2722 preterm infants were included in this retrospective study. PNI level and clinical records of these neonates (adverse pregnancy and birth history, amniotic fluid contamination, nuchal cord, placental abnormality, mode of delivery, gender and birth weight of neonates, Apgar scores) were collected. The clinical features of the infants with and without NRDS were compared. Logistic regression analysis was used to evaluate the relationship between PNI and NRDS in newborns with different gestational ages.

Results: There were 1226 neonates with NRDS and 1496 without NRDS. The differences in the proportions of placenta abnormality, cesarean section, and small for gestational age (SGA) among infants with 34-37 weeks, 28⁺¹-33⁺⁶ weeks, and ≤28 weeks gestational age were statistically significant. Logistic analysis showed that cesarean section (odds ratio (OR): 1.550, 95% confidence interval (CI): 1.197-2.007, p=0.001), and low PNI (OR: 1.417, 95% CI: 1.110-1.808, p=0.005) were associated with NRDS in infants born at 34-37 weeks gestational. Adverse pregnancy and birth history (OR: 1.507, 95% CI: 1.124-2.019, p=0.006), SGA (OR: 1.994, 95% CI: 1.455-2.733, p<0.001), and low PNI (OR: 1.626, 95% CI: 1.230-2.149, p=0.001) were associated with NRDS in infants with 28⁺¹-33⁺⁶ weeks gestational age. Low PNI (OR: 5.512, 95% CI: 1.555-19.536, p=0.008) was associated with NRDS in infants with ≤28 weeks gestational age.

Conclusion: The risk factors for NRDS in preterm infants with different gestational ages were different. But the low PNI level is associated with an increased risk of NRDS in preterm infants with all different gestational ages.

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低预后营养指数（PNI）水平与不同胎龄早产儿患新生儿呼吸窘迫综合征的风险增加有关：一项回顾性研究。

背景：新生儿呼吸窘迫综合征（NRDS）常见于早产儿。预后营养指数（PNI）（（白蛋白（g/L）+（5×总淋巴细胞计数（109/L））是营养和免疫水平的综合指标，与多种疾病相关。不同胎龄新生儿的 PNI 与 NRDS 风险之间的关系仍不清楚：这项回顾性研究共纳入了 2722 名早产儿。收集了这些新生儿的 PNI 水平和临床记录（不良妊娠和分娩史、羊水污染、脐带、胎盘异常、分娩方式、新生儿性别和出生体重、Apgar 评分）。对患有和未患有 NRDS 的婴儿的临床特征进行了比较。采用逻辑回归分析评估不同胎龄新生儿的 PNI 与 NRDS 之间的关系：结果：1226 名新生儿患有 NRDS，1496 名未患有 NRDS。胎龄在 34-37 周、28+1-33+6 周和≤28 周的新生儿中，胎盘异常、剖宫产和小于胎龄（SGA）的比例差异有统计学意义。逻辑分析显示，剖宫产（几率比（OR）：1.550，95% 置信区间（CI）：1.197-2.007，P=0.001）和低 PNI（OR：1.417，95% CI：1.110-1.808，P=0.005）与胎龄 34-37 周出生婴儿的 NRDS 相关。不良孕产史（OR：1.507，95% CI：1.124-2.019，p=0.006）、SGA（OR：1.994，95% CI：1.455-2.733，pp=0.001）与孕龄 28+1-33+6 周婴儿的 NRDS 相关。胎龄≤28周的婴儿中，低PNI（OR：5.512，95% CI：1.555-19.536，P=0.008）与NRDS相关：结论：不同胎龄的早产儿发生 NRDS 的风险因素不同。结论：不同胎龄的早产儿发生 NRDS 的风险因素不同，但 PNI 水平低与所有不同胎龄的早产儿发生 NRDS 的风险增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of General Medicine Medicine-General Medicine

自引率

0.00%

发文量

1113

审稿时长

16 weeks

期刊介绍： The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.