Analysis of the Natural Course of Quiescent Macular Neovascularization with Optical Coherence Tomography Angiography.

IF 1.4 4区医学 Q3 OPHTHALMOLOGY

European Journal of Ophthalmology Pub Date : 2024-11-18 DOI:10.1177/11206721241298025

Yeliz Delibay Akgun, Emin Kurt, Muhammed Altinisik

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引用次数: 0

Abstract

Purpose: This study investigates the natural progression of quiescent macular neovascularization (qMNV) using optical coherence tomography angiography (OCTA).

Methods: The study monitored 30 eyes of 28 qMNV patients over a period of at least six months. Best-corrected visual acuity (BCVA), optical coherence tomography (OCT), and OCTA were used to perform qualitative and quantitative analyses, noting any cases of activation during follow-up.

Results: Among the 30 eyes (14 female, mean age 69.70 ± 7.63 years), 21 had age-related macular degeneration (AMD) and 9 had pachychoroid neovasculopathy (PNV). The mean follow-up duration was 18.9 months. There were no significant changes in qualitative morphological features, BCVA, or choroidal thickness (p > 0.05). However, there was a statistically significant increase in the areas of MNV and flow (p = 0.043 and p = 0.018, respectively). BCVA and MNV area showed no significant correlation (p = 0.103). Four cases (13.33%) showed activation after an average follow-up period of 27.75 months (6 to 48). Additionally, extrafoveal location was identified as a significant risk factor for exudation (p = 0.033).

Conclusion: OCTA is a valuable tool for monitoring qMNV and identifying potential predictors of disease activation. The qMNV area may increase over time, even in the absence of activation. Extrafoveal location appears to be a potential risk factor for qMNV activation.

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利用光学相干断层扫描血管造影术分析静止黄斑新生血管的自然病程。

目的：本研究使用光学相干断层血管造影（OCTA）对静止性黄斑新生血管（qMNV）的自然进展进行研究：该研究对 28 名 qMNV 患者的 30 只眼睛进行了至少 6 个月的监测。采用最佳矫正视力（BCVA）、光学相干断层扫描（OCT）和 OCTA 进行定性和定量分析，并记录随访期间的任何激活病例：在 30 只眼睛（14 只为女性，平均年龄为 69.70 ± 7.63 岁）中，21 只患有老年性黄斑变性（AMD），9 只患有睫状体新生血管病（PNV）。平均随访时间为 18.9 个月。定性形态特征、BCVA 或脉络膜厚度均无明显变化（P > 0.05）。然而，MNV 和血流的面积却有统计学意义的增加（分别为 p = 0.043 和 p = 0.018）。BCVA 与 MNV 面积无明显相关性（p = 0.103）。四例患者（13.33%）在平均 27.75 个月（6 至 48 个月）的随访后出现激活。此外，眼底外位置被确定为渗出的一个重要风险因素（p = 0.033）：结论：OCTA 是监测 qMNV 和确定疾病激活潜在预测因素的重要工具。即使没有激活，qMNV 的面积也可能随着时间的推移而增加。视网膜外位置似乎是qMNV激活的潜在风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Ophthalmology 医学-眼科学

CiteScore

3.60

自引率

0.00%

发文量

372

审稿时长

3-8 weeks

期刊介绍： The European Journal of Ophthalmology was founded in 1991 and is issued in print bi-monthly. It publishes only peer-reviewed original research reporting clinical observations and laboratory investigations with clinical relevance focusing on new diagnostic and surgical techniques, instrument and therapy updates, results of clinical trials and research findings.