D-Dimer/Platelet Ratio Predicts in-Hospital Death in Patients with Acute Type a Aortic Dissection.

IF 2.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
International Journal of General Medicine Pub Date : 2024-11-11 eCollection Date: 2024-01-01 DOI:10.2147/IJGM.S490858
Ani Zhao, Yanchun Peng, Baolin Luo, Yaqin Chen, Liangwan Chen, Yanjuan Lin
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引用次数: 0

Abstract

Purpose: Acute Type A aortic dissection (ATAAD) is a rare and life-threatening aortic disease. This study was aimed at the potential of the D-dimer to platelet count ratio (DPR) as a prognostic indicator of ATAAD.

Patients and methods: This study retrospectively analyzed ATAAD patients who were admitted to the Department of Cardiac Surgery, Fujian Medical University Union Hospital from January 2022 to April 2023. Patients were divided into survival (n = 173) and death (n = 24) groups based on whether death occurred. The primary outcome was death, and the secondary outcome was adverse hospitalization, including new postoperative arrhythmias, acute renal insufficiency, acute liver insufficiency, pleural effusion, length of ICU stay, mechanical ventilation length, and length of stay. The logistic regression model was used to analyze the relationship between DPR and in-hospital death, and the receiver operating characteristic curve (ROC) was drawn to analyze the predictive value of DPR for in-hospital death of ATAAD patients.

Results: Of the 197 patients included, 24 died, and the in-hospital mortality rate was 12.2%. There was a significant difference in diastolic blood pressure (P < 0.05). In terms of laboratory indexes, total bilirubin, direct bilirubin, indirect bilirubin, D-dimer, red blood cell volume distribution width, and DPR in the death group were higher than those in the survival group, with statistical significance (P < 0.05). Operation duration, hospital stay, ICU stay, mechanical ventilation time, and acute renal insufficiency in the death group were higher than those in the survival group (P < 0.05). Univariate analysis and multivariate analysis showed that DPR > 0.0305 ug/mL was an independent risk factor for death in ATAAD patients.

Conclusion: Increased DPR is independently associated with in-hospital death in patients with ATAAD.

D-Dimer/Platelet 比率可预测急性 a 型主动脉夹层患者的院内死亡。
目的:急性A型主动脉夹层(ATAAD)是一种罕见且危及生命的主动脉疾病。本研究旨在探讨D-二聚体与血小板计数比值(DPR)作为ATAAD预后指标的潜力:本研究回顾性分析了2022年1月至2023年4月期间福建医科大学附属协和医院心脏外科收治的ATAAD患者。根据是否死亡将患者分为生存组(173 人)和死亡组(24 人)。主要结局为死亡,次要结局为不良住院情况,包括术后新发心律失常、急性肾功能不全、急性肝功能不全、胸腔积液、ICU住院时间、机械通气时间和住院时间。采用逻辑回归模型分析DPR与院内死亡之间的关系,并绘制接收器操作特征曲线(ROC)分析DPR对ATAAD患者院内死亡的预测价值:在纳入的 197 例患者中,24 例死亡,院内死亡率为 12.2%。舒张压差异明显(P<0.05)。在实验室指标方面,死亡组的总胆红素、直接胆红素、间接胆红素、D-二聚体、红细胞体积分布宽度、DPR均高于存活组,差异有统计学意义(P < 0.05)。死亡组的手术时间、住院时间、重症监护室住院时间、机械通气时间和急性肾功能不全均高于存活组(P < 0.05)。单变量分析和多变量分析显示,DPR > 0.0305 ug/mL是ATAAD患者死亡的独立危险因素:结论:DPR升高与ATAAD患者院内死亡密切相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Journal of General Medicine
International Journal of General Medicine Medicine-General Medicine
自引率
0.00%
发文量
1113
审稿时长
16 weeks
期刊介绍: The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.
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