Sonodynamic and Acoustically Responsive Nanodrug Delivery System: Cancer Application.

IF 6.6 2区 医学 Q1 NANOSCIENCE & NANOTECHNOLOGY
International Journal of Nanomedicine Pub Date : 2024-11-11 eCollection Date: 2024-01-01 DOI:10.2147/IJN.S496028
Yong-Gyu Jeong, Joo-Hwan Park, Dongwoo Khang
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引用次数: 0

Abstract

The advent of acoustically responsive nanodrugs that are specifically optimized for sonodynamic therapy (SDT) is a novel approach for clinical applications. Examining the therapeutic applications of sono-responsive drug delivery systems, understanding their dynamic response to acoustic stimuli, and their crucial role in enhancing targeted drug delivery are intriguing issues for current cancer treatment. Specifically, the suggested review covers SDT, a modality that enhances the cytotoxic activity of specific compounds (sonosensitizers) using ultrasound (US). Notably, SDT offers significant advantages in cancer treatment by utilizing US energy to precisely target and activate sonosensitizers toward deep-seated malignant sites. The potential mechanisms underlying SDT involve the generation of radicals from sonosensitizers, physical disruption of cell membranes, and enhanced drug transport into cells via US-assisted sonoporation. In particular, SDT is emerging as a promising modality for noninvasive, site-directed elimination of solid tumors. Given the complexity and diversity of tumors, many studies have explored the integration of SDT with other treatments to enhance the overall efficacy. This trend has paved the way for SDT-based multimodal synergistic cancer therapies, including sonophototherapy, sonoimmunotherapy, and sonochemotherapy. Representative studies of these multimodal approaches are comprehensively presented, with a detailed discussion of their underlying mechanisms. Additionally, the application of audible sound waves in biological systems is explored, highlighting their potential to influence cellular processes and enhance therapeutic outcomes. Audible sound waves can modulate enzyme activities and affect cell behavior, providing novel avenues for the use of sound-based techniques in medical applications. This review highlights the current challenges and prospects in the development of SDT-based nanomedicines in this rapidly evolving research field. The anticipated growth of this SDT-based therapeutic approach promises to significantly improve the precision of cancer treatment.

声动力和声响应纳米给药系统:癌症应用。
专为声动力疗法(SDT)优化的声响应纳米药物的出现是临床应用的一种新方法。研究声响应给药系统的治疗应用,了解其对声学刺激的动态响应,以及它们在增强靶向给药方面的关键作用,是当前癌症治疗中引人关注的问题。具体而言,建议的综述涉及 SDT,这是一种利用超声波(US)增强特定化合物(声敏化剂)细胞毒性活性的模式。值得注意的是,SDT 在癌症治疗中具有显著优势,它利用 US 能量将声波增敏剂精确瞄准并激活深层恶性部位。SDT 的潜在机制包括声波增敏剂产生自由基、对细胞膜造成物理破坏以及通过 US 辅助的声波修复增强药物在细胞内的传输。特别是,SDT 正在成为一种很有前景的非侵入性、定点消除实体肿瘤的方法。鉴于肿瘤的复杂性和多样性,许多研究都在探索将 SDT 与其他治疗方法相结合,以提高整体疗效。这一趋势为基于 SDT 的多模式协同癌症疗法铺平了道路,包括声光疗法、声免疫疗法和声化学疗法。本文全面介绍了这些多模式疗法的代表性研究,并对其基本机制进行了详细讨论。此外,还探讨了声波在生物系统中的应用,强调了声波影响细胞过程和提高治疗效果的潜力。可听声波可以调节酶的活性并影响细胞的行为,为在医学应用中使用声基技术提供了新的途径。本综述重点介绍了在这一快速发展的研究领域开发基于 SDT 的纳米药物所面临的挑战和前景。这种基于 SDT 的治疗方法的预期发展有望显著提高癌症治疗的精确性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Journal of Nanomedicine
International Journal of Nanomedicine NANOSCIENCE & NANOTECHNOLOGY-PHARMACOLOGY & PHARMACY
CiteScore
14.40
自引率
3.80%
发文量
511
审稿时长
1.4 months
期刊介绍: The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area. With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field. Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.
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