Development of silicone-based phantoms for biomedical optics from 400 to 1550 nm.

Abstract

This work describes the development of silicone-based evaluation phantoms for biomedical optics in the wavelength range from 400 to 1550 nm. The absorption coefficient μ _a and the reduced scattering coefficient ${\mu }_{\text{s}}^{\text{'}}$ were determined using an integrating sphere setup. Zirconium dioxide pigments were used as scatterers and carbon black as absorbers. We developed an in-house manufacturing process using a Hauschild SpeedMixer to ensure reproducibility. A set of nine cubic phantoms with three different reduced scattering and absorption coefficients was produced. Prediction of the μ _a and ${\mu }_{\text{s}}^{\text{'}}$ was done by using the weighted mass concentrations of the used materials. The average prediction accuracy over all wavelengths and phantoms is 1.0% for the reduced scattering coefficient and 3.5% for the absorption coefficient.