Carvacrol incorporation into novel controlled-release mucoadhesive systems for oral polymicrobial biofilm control.

IF 2.6 3区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biofouling Pub Date : 2024-11-18 DOI:10.1080/08927014.2024.2426759

Luciana Solera Sales, Aline Leite de Farias, Andréia Bagliotti Meneguin, Hernane da Silva Barud, Fernanda Lourenção Brighenti

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Abstract

The aim of this study was to evaluate carvacrol antimicrobial activity in polymicrobial biofilms using a novel controlled-release mucoadhesive systems developed from biopolymers. The natural polymers gellan gum and sodium alginate were used in different concentrations for the development of films, tablets and microparticles containing carvacrol. The systems were characterized as regard their morphological characteristics, carvacrol release and mucoadhesion. Furthermore, the antimicrobial activity of the systems was evaluated on polymicrobial biofilms through biomass quantification and microbial viability assessment. Carvacrol release profile from films, tablets and microparticles was similar; nearly 100% of the carvacrol was released within 15 min. Films showed the best mucoadhesion values. Scanning Electron Microscopy images showed that the films presented a continuous and smooth surface, and the tablets showed a continuous surface with a polymer web appearance. The microparticles were spherical in shape. The films containing carvacrol showed the highest biomass and microbial viability reduction, followed by the tablets. The findings of this study showed that carvacrol incorporated into films and tablets presented antimicrobial activity on polymicrobial biofilm. Controlled-release mucoadhesive systems is a process little explored in dentistry, being the differential of this work, and with great innovative potential for the management of dental diseases.

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将香芹酚加入新型控释粘液黏附系统以控制口腔多微生物生物膜。

本研究旨在利用生物聚合物开发的新型控释粘液黏附系统，评估香芹酚在多微生物生物膜中的抗菌活性。天然聚合物结冷胶和海藻酸钠以不同浓度被用于开发含有香芹酚的薄膜、片剂和微颗粒。对这些系统的形态特征、香芹酚释放量和粘附性进行了表征。此外，还通过生物量定量和微生物活力评估，评估了这些系统在多微生物生物膜上的抗菌活性。薄膜、片剂和微粒的香芹酚释放曲线相似；近 100%的香芹酚在 15 分钟内释放。薄膜的粘附性最好。扫描电子显微镜图像显示，薄膜的表面连续而光滑，片剂的表面连续而呈聚合物网状。微粒呈球形。含有香芹酚的薄膜显示出最高的生物量和微生物活力降低率，其次是片剂。这项研究结果表明，在薄膜和片剂中添加香芹酚对多微生物生物膜具有抗菌活性。控释粘液黏附系统是牙科领域探索较少的一种工艺，也是这项工作的不同之处，在牙科疾病的治疗方面具有巨大的创新潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biofouling 生物-海洋与淡水生物学

CiteScore

5.00

自引率

7.40%

发文量

审稿时长

1.7 months

期刊介绍： Biofouling is an international, peer-reviewed, multi-discliplinary journal which publishes original articles and mini-reviews and provides a forum for publication of pure and applied work on protein, microbial, fungal, plant and animal fouling and its control, as well as studies of all kinds on biofilms and bioadhesion. Papers may be based on studies relating to characterisation, attachment, growth and control on any natural (living) or man-made surface in the freshwater, marine or aerial environments, including fouling, biofilms and bioadhesion in the medical, dental, and industrial context. Specific areas of interest include antifouling technologies and coatings including transmission of invasive species, antimicrobial agents, biological interfaces, biomaterials, microbiologically influenced corrosion, membrane biofouling, food industry biofilms, biofilm based diseases and indwelling biomedical devices as substrata for fouling and biofilm growth, including papers based on clinically-relevant work using models that mimic the realistic environment in which they are intended to be used.