Idiopathic apical orbital inflammation: clinical features and outcomes.

IF 3.3 4区 医学 Q1 OPHTHALMOLOGY
Sonia Huang, Jessica Y Tong, Terence W Ang, Thomas G Hardy, Alan McNab, Dinesh Selva
{"title":"Idiopathic apical orbital inflammation: clinical features and outcomes.","authors":"Sonia Huang, Jessica Y Tong, Terence W Ang, Thomas G Hardy, Alan McNab, Dinesh Selva","doi":"10.1016/j.jcjo.2024.10.012","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Idiopathic apical orbital inflammation (AOI) is used to describe inflammation involving the posterior third of the orbit where no specific cause can be identified. It is a rare entity in which the presentation can vary widely. We aim to describe a case series of patients with idiopathic AOI and their clinicoradiological features and visual outcomes.</p><p><strong>Method: </strong>Retrospective multi-centre case series involving patients with idiopathic AOI.</p><p><strong>Results: </strong>Seven patients were included. The mean age was 50.3 ± 18.4 years (range: 31-84 years). The left eye was involved in the majority of patients (4, 57.1%), with the most common presenting clinical symptoms and signs being limitation of extraocular movements (6, 85.7%), periorbital pain (4, 57.1%), and blurred vision (4, 57.1%). Optic neuropathy was present in 3 (42.9%) patients. Three patients (42.9%) underwent an orbital biopsy, which were all consistent with nonspecific inflammation. Medical treatment was used for all patients in the form of oral steroids (5, 71.4%) or nonsteroidal anti-inflammatories (1, 14.3%). Two (28.6%) patients had additional immunosuppression. At last follow-up, 2 (28.6%) patients had achieved complete resolution of all of their symptoms, 2 (28.6%) patients had significant clinical improvement with mild residual disease, 2 (28.6%) had stable disease, and 1 (28.6%) was lost to follow-up.</p><p><strong>Conclusion: </strong>Idiopathic AOI is a rare condition that can present with a wide variety of symptoms and be potentially blinding. Patients responded well to oral corticosteroids, but biopsy and additional immunosuppressive agents should be considered in those with recurrent, poorly responsive, or atypical disease.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jcjo.2024.10.012","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Idiopathic apical orbital inflammation (AOI) is used to describe inflammation involving the posterior third of the orbit where no specific cause can be identified. It is a rare entity in which the presentation can vary widely. We aim to describe a case series of patients with idiopathic AOI and their clinicoradiological features and visual outcomes.

Method: Retrospective multi-centre case series involving patients with idiopathic AOI.

Results: Seven patients were included. The mean age was 50.3 ± 18.4 years (range: 31-84 years). The left eye was involved in the majority of patients (4, 57.1%), with the most common presenting clinical symptoms and signs being limitation of extraocular movements (6, 85.7%), periorbital pain (4, 57.1%), and blurred vision (4, 57.1%). Optic neuropathy was present in 3 (42.9%) patients. Three patients (42.9%) underwent an orbital biopsy, which were all consistent with nonspecific inflammation. Medical treatment was used for all patients in the form of oral steroids (5, 71.4%) or nonsteroidal anti-inflammatories (1, 14.3%). Two (28.6%) patients had additional immunosuppression. At last follow-up, 2 (28.6%) patients had achieved complete resolution of all of their symptoms, 2 (28.6%) patients had significant clinical improvement with mild residual disease, 2 (28.6%) had stable disease, and 1 (28.6%) was lost to follow-up.

Conclusion: Idiopathic AOI is a rare condition that can present with a wide variety of symptoms and be potentially blinding. Patients responded well to oral corticosteroids, but biopsy and additional immunosuppressive agents should be considered in those with recurrent, poorly responsive, or atypical disease.

特发性眼眶顶部炎症:临床特征和结果。
背景:特发性眼眶顶部炎症(AOI)是指眼眶后三分之一处的炎症,无法确定具体病因。这是一种罕见的病症,其表现千差万别。我们旨在描述特发性眶尖炎患者的病例系列及其临床放射学特征和视觉效果:回顾性多中心病例系列,涉及特发性 AOI 患者:结果:共纳入七名患者。平均年龄为 50.3 ± 18.4 岁(31-84 岁)。大多数患者的左眼受累(4 例,57.1%),最常见的临床症状和体征是眼外活动受限(6 例,85.7%)、眶周疼痛(4 例,57.1%)和视力模糊(4 例,57.1%)。3名患者(42.9%)出现视神经病变。三名患者(42.9%)接受了眼眶活组织检查,结果均为非特异性炎症。所有患者都接受了口服类固醇(5 例,占 71.4%)或非类固醇抗炎药(1 例,占 14.3%)的药物治疗。两名患者(28.6%)接受了额外的免疫抑制治疗。在最后一次随访中,2 名患者(28.6%)的所有症状完全消失,2 名患者(28.6%)临床症状明显改善,但有轻微残留,2 名患者(28.6%)病情稳定,1 名患者(28.6%)失去随访机会:特发性视网膜病变是一种罕见病,可表现出多种症状,具有潜在的致盲性。患者对口服皮质类固醇反应良好,但对于病情反复、反应不佳或不典型的患者,应考虑进行活组织检查和使用额外的免疫抑制剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
3.20
自引率
4.80%
发文量
223
审稿时长
38 days
期刊介绍: Official journal of the Canadian Ophthalmological Society. The Canadian Journal of Ophthalmology (CJO) is the official journal of the Canadian Ophthalmological Society and is committed to timely publication of original, peer-reviewed ophthalmology and vision science articles.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信