Neurofilament Light Chain Is Associated With Acute Mountain Sickness

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior Pub Date : 2024-11-17 DOI:10.1002/brb3.70165

Klaus Berek, Anna Lindner, Franziska Di Pauli, Gabriel Bsteh, Benedikt Treml, Markus Ponleitner, Clemens Engler, Axel Kleinsasser, Thomas Berger, Maria Wille, Martin Burtscher, Florian Deisenhammer, Harald Hegen

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Abstract

Background

Neurological symptoms are common in acute mountain sickness (AMS); however, the extent of neuroaxonal damage remains unclear. Neurofilament light chain (NfL) is an established blood biomarker for neuroaxonal damage.

Objective

To investigate whether plasma (p) NfL levels increase after simulated altitude exposure, correlate with the occurrence of AMS, and might be mitigated by preacclimatization.

Methods

Healthy subjects were exposed to simulated high altitude (4500 m) by the use of a normobaric hypoxic chamber at the University of Innsbruck two times, that is, within Cycle 1 (C1) over 12 h, and within Cycle 2 (C2) for another 12 h but with a random assignment to prior acclimatization or sham acclimatization. Before each cycle (measurement [M] 1 and 3) and after each cycle (M2 and M4), clinical data (arterial oxygen saturation [SaO₂], heart rate, and Lake Louise AMS score [LLS]) and plasma samples were collected. pNfL was measured using single-molecule array (Simoa) technique.

Results

pNfL levels did not significantly change within each study cycle, but increased over the total study period (M1: 4.57 [3.34–6.39], M2: 4.58 [3.74–6.0], M3: 5.64, and M4: 6.53 [4.65–7.92] pg/mL, p < 0.001). Subjects suffering from AMS during the study procedures showed higher pNfL levels at M4 (6.80 [6.19–8.13] vs. 5.75 [4.17–7.35], p = 0.048), a higher total pNfL increase (2.88 [1.21–3.48] vs. 0.91 [0.53–1.48], p = 0.022) compared to subjects without AMS. An effect of preacclimatization on pNfL levels could not be observed.

Conclusions

pNfL increases alongside exposure to simulated altitude and is associated with AMS.

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神经丝蛋白轻链与急性晕山症有关

背景：神经系统症状在急性高山反应（AMS）中很常见，但神经轴受损的程度仍不清楚。神经丝蛋白轻链（NfL）是神经轴受损的既定血液生物标志物：方法：在因斯布鲁克大学（University of Innsbruck）使用常压缺氧舱将健康受试者暴露于模拟高海拔地区（4500 米）两次，即在第一周期（C1）中暴露 12 小时，在第二周期（C2）中再暴露 12 小时，但随机分配预先适应或假适应。在每个周期（测量[M] 1 和 3）之前和之后（M2 和 M4），收集临床数据（动脉血氧饱和度[SaO2]、心率和路易斯湖 AMS 评分[LLS]）和血浆样本。结果：pNfL 水平在每个研究周期内没有显著变化，但在整个研究期间有所上升（M1：4.57 [3.34-6.39]；M2：4.58 [3.74-6.0]；M3：5.64；M4：5.64）：结论：pNfL 随暴露于模拟海拔高度而增加，并与 AMS 相关。

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

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