A Cascade Synthesis of Furo-Pyrrolo-Pyridines via Pd(II)-Catalyzed Dual N-H/C Annulative-Cyclization.

IF 3.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2024-11-18 DOI:10.1002/chem.202403470

Hirendra Nath Dhara, Supriya Manna, Bhisma K Patel

引用次数: 0

Abstract

A Pd(II)-catalyzed non-template synthesis of furo[2,3-b]pyrrolo[2,3-d]pyridines from b-ketodinitriles and buta-1,3-diynes has been accomplished via dual annulative cyclization. The participation of both the nitrile (-CN) groups led to the concurrent construction of three heterocycles viz. furan, pyrrole, and pyridine forming C-C, C=C, C-O, C-N, and C=N bonds in one pot. The synthetic utility of the protocol was further demonstrated through a few post-synthetic manipulations.

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通过 Pd(II)-Catalyzed Dual N-H/C Annulative-Cyclization 级联合成呋喃并吡咯并吡啶。

在钯(II)催化下，通过双环化作用，从 b-ketodinitriles 和 buta-1,3-diynes 合成了呋喃并[2,3-b]吡咯并[2,3-d]吡啶。由于两个腈（-CN）基团的参与，在一次反应中同时生成了三个杂环，即呋喃、吡咯和吡啶，形成了 C-C、C=C、C-O、C-N 和 C=N 键。通过一些合成后操作，进一步证明了该方案的合成实用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

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