Synthesis and Cytotoxicity Against M-HeLa, HuTu 80, and MCF-7 Human Cancer Cells of the First Nucleoterpenoids of the Isosteviol Diterpenoid Platform

IF 0.8 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2024-11-13 DOI:10.1007/s10600-024-04520-2

O. V. Andreeva, M. G. Belenok, I. Yu. Strobykina, L. F. Saifina, A. P. Lyubina, A. S. Sapunova, A. D. Voloshina, B. F. Garifullin, V. E. Semenov, V. E. Kataev

引用次数: 0

Abstract

Conjugates of the diterpenoid isosteviol with uracil and 6-methyluracil (nucleoterpenoids) were synthesized and showed moderate in vitro cytotoxicity (IC₅₀ values in the range 11.6–51.0 μM) against M-HeLa, HuTu 80, and MCF-7 human cancer cells.

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Isosteviol 二萜平台的首个核苷酸类化合物的合成及其对 M-HeLa、HuTu 80 和 MCF-7 人癌细胞的细胞毒性

合成了二萜类异雌二醇与尿嘧啶和 6-甲基尿嘧啶（核苷酸）的共轭物，并对 M-HeLa、HuTu 80 和 MCF-7 人类癌细胞显示出适度的体外细胞毒性（IC50 值范围为 11.6-51.0 μM）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.