Secondary Metabolites of Two Desert Endophytic Fungi Neocamarosporum sp. and Alternaria sp.

IF 0.8 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2024-11-06 DOI:10.1007/s10600-024-04511-3

Hua-Yang Pan, Hua-Guang Liu, Hui-Ying Liu, Yu Liu, Shuang-Mei Yan, Xiao-Long Zhao, Du-Qiang Luo

引用次数: 0

Abstract

Four new compounds (1–4) along with twelve known compounds (5–16) were isolated from the fermentation broth of two desert endophytic fungi Neocamarosporum sp. HM 175 and Alternaria sp. HM 213. The structures of the compounds were elucidated by ESI-MS and NMR data. The PTP1B inhibitory activity results showed that compounds 2, 5, 11, 12, and 13 exhibited certain inhibitory activity on PTP1B. The activity test of these compounds provided potential drug lead compounds for the research and development of new PTP1B inhibitors.

Abstract Image

查看原文本刊更多论文

两种沙漠内生真菌 Neocamarosporum sp.

从两种沙漠内生真菌 Neocamarosporum sp. HM 175 和 Alternaria sp. HM 213 的发酵液中分离出了四种新化合物（1-4）和十二种已知化合物（5-16）。通过 ESI-MS 和 NMR 数据阐明了这些化合物的结构。PTP1B 抑制活性结果表明，化合物 2、5、11、12 和 13 对 PTP1B 具有一定的抑制活性。这些化合物的活性测试为研究和开发新的 PTP1B 抑制剂提供了潜在的药物先导化合物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.