The possible role of hypoxia-induced exosomes on the fibroblast metabolism in idiopathic pulmonary fibrosis

IF 6.9 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Biomedicine & Pharmacotherapy Pub Date : 2024-11-16 DOI:10.1016/j.biopha.2024.117680

Noé Alvarado-Vasquez , Claudia Rangel-Escareño , Javier de Jesús Ramos-Abundis , Carina Becerril , María Cristina Negrete-García

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引用次数: 0

Abstract

Idiopathic pulmonary fibrosis (IPF) has a high incidence and prevalence among patients over 65 years old. While its exact etiology remains unknown, several risk factors have recently been identified. Hypoxia is associated with IPF due to the abnormal architecture of lung parenchyma and the accumulation of extracellular matrix produced by activated fibroblasts. Exosomes play a crucial role in intercellular communication during both physiological and pathological processes, including hypoxic diseases like IPF. Recent findings suggest that a hypoxic microenvironment influences the content of exosomes in various diseases, thereby altering cellular metabolism. Although the role of exosomes in IPF is an emerging area of research, the significance of hypoxic exosomes as inducers of metabolic reprogramming in fibroblasts is still underexplored. In this study, we analyze and discuss the relationship between hypoxia, exosomal cargo, and the metabolic reprogramming of fibroblasts in the progression of IPF.

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缺氧诱导的外泌体对特发性肺纤维化中成纤维细胞代谢的可能作用

特发性肺纤维化（IPF）在 65 岁以上的患者中发病率和流行率都很高。虽然其确切病因尚不清楚，但最近已确定了几个风险因素。由于肺实质结构异常以及活化的成纤维细胞产生的细胞外基质堆积，缺氧与 IPF 有关。外泌体在生理和病理过程（包括 IPF 等缺氧性疾病）中的细胞间通信中发挥着至关重要的作用。最近的研究结果表明，缺氧微环境会影响各种疾病中外泌体的含量，从而改变细胞的新陈代谢。虽然外泌体在 IPF 中的作用是一个新兴的研究领域，但低氧外泌体作为成纤维细胞代谢重编程诱导剂的意义仍未得到充分探索。在本研究中，我们分析并讨论了IPF进展过程中缺氧、外泌体货物和成纤维细胞代谢重编程之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedicine & Pharmacotherapy 医学-药学

CiteScore

11.90

自引率

2.70%

发文量

1621

审稿时长

48 days

期刊介绍： Biomedicine & Pharmacotherapy stands as a multidisciplinary journal, presenting a spectrum of original research reports, reviews, and communications in the realms of clinical and basic medicine, as well as pharmacology. The journal spans various fields, including Cancer, Nutriceutics, Neurodegenerative, Cardiac, and Infectious Diseases.