The impact of different types of physical activity on the risk of knee osteoarthritis: A Mendelian randomization study

IF 1.6 4区医学 Q3 ORTHOPEDICS

Knee Pub Date : 2024-11-16 DOI:10.1016/j.knee.2024.10.019

Guiguan Wang , Long Chen , Yancheng Chen , Jie Xu

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引用次数: 0

Abstract

Background

We aim to evaluate the causal relationship between different types of physical activity and the risk of knee osteoarthritis (KOA) through a two-sample Mendelian randomization study.

Methods

We performed a two-sample Mendelian randomization analysis using publicly available Genome-wide association study associated with physical activity (460 376 individuals) and KOA (403 124 individuals). Two-sample Mendelian randomization analyses were performed to investigate the effects of exposure traits on KOA risk.

Results

In this Mendelian randomization analysis, we investigated the impact of different types of physical activity on the risk of KOA. Light do-it-yourself and walking for pleasure demonstrated a protective effect on the risk of KOA (P = 8.19 × 10−4 and P = 4.24 × 10−6, respectively). No statistically significant differences were observed for heavy do-it-yourself, strenuous sports, other exercises or physical inactivity.

Conclusion

This study has revealed that engaging in light do-it-yourself activities and walking may serve as potential protective factors against KOA. These findings underscore the significance of introducing such activities into public health strategies designed for the prevention and management of KOA. Additional research is warranted to reveal the underlying mechanisms further.

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不同类型的体育锻炼对膝关节骨性关节炎风险的影响：孟德尔随机研究

研究背景我们旨在通过一项双样本孟德尔随机研究，评估不同类型的体育锻炼与膝关节骨性关节炎（KOA）风险之间的因果关系：我们利用公开的与体育锻炼（460 376 人）和 KOA（403 124 人）相关的全基因组关联研究进行了双样本孟德尔随机分析。结果表明，暴露特质对KOA风险的影响是双样本孟德尔随机分析的结果：在这项孟德尔随机分析中，我们研究了不同类型的体育锻炼对 KOA 风险的影响。轻度自己动手和为娱乐而步行对 KOA 风险有保护作用（P = 8.19 × 10-4 和 P = 4.24 × 10-6）。重体力劳动、剧烈运动、其他锻炼或缺乏运动在统计学上没有明显差异：本研究揭示了参与轻度动手活动和步行可能是预防 KOA 的潜在保护因素。这些发现强调了在预防和管理 KOA 的公共卫生战略中引入此类活动的重要性。要进一步揭示其潜在机制，还需要进行更多的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Knee 医学-外科

CiteScore

3.80

自引率

5.30%

发文量

171

审稿时长

6 months

期刊介绍： The Knee is an international journal publishing studies on the clinical treatment and fundamental biomechanical characteristics of this joint. The aim of the journal is to provide a vehicle relevant to surgeons, biomedical engineers, imaging specialists, materials scientists, rehabilitation personnel and all those with an interest in the knee. The topics covered include, but are not limited to: • Anatomy, physiology, morphology and biochemistry; • Biomechanical studies; • Advances in the development of prosthetic, orthotic and augmentation devices; • Imaging and diagnostic techniques; • Pathology; • Trauma; • Surgery; • Rehabilitation.