Histopathological pattern in endometrial biopsies in reproductive age group and Post-menopausal women.

IF 0.8 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Journal of the Pakistan Medical Association Pub Date : 2024-11-01 DOI:10.47391/JPMA.11352

Farah Fatima Abbas, Uzma Bukhari, Nehad Khan, Fatima Arshad, Saba Kamil

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引用次数: 0

Abstract

Objectives: To identify and analyse the different types and frequencies of morphological pattern in endometrial biopsies along with their associated diagnoses across different age groups.

Methods: The cross-sectional study was conducted at the Histopathology Section of the Dow Diagnostics Reference and Research Laboratory, Dow University Health Sciences, Karachi, from October 2022 to October 2023. Data was obtained from pre-existing medical record of samples of endometrial biopsies. Open Epi sample size calculator is used for the estimation of sample size. The patients were divided into two aged-based groups; reproductive age ≤45 years in group 1 and postmenopause age ≥46 years in group 2. The histological diagnosis was made by a consultant histopathologist.

Results: Of the 430 endometrial biopsies 222(51.6%) were in group 1 and 208(48.4%) were in group 2. In both groups, the most common finding was polyps 271(63%). Malignant changes were found in 12(5.7%) group 2 cases compared to 4(1.8%) group 1 cases.

Conclusions: The most common endometrial lesion in both age groups was endometrial polyp. Malignant changes were seen more in postmenopausal women compared to those in the reproductive age group.

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育龄期和绝经后妇女子宫内膜活检组织病理学模式。

目的确定并分析不同年龄组子宫内膜活组织检查中形态模式的不同类型和频率，以及与之相关的诊断：这项横断面研究于 2022 年 10 月至 2023 年 10 月在卡拉奇陶氏大学健康科学学院陶氏诊断参考与研究实验室组织病理学组进行。数据来自子宫内膜活检样本的已有医疗记录。样本量的估算使用 Open Epi 样本量计算器。患者按年龄分为两组：生育年龄≤45岁为第一组，绝经后年龄≥46岁为第二组，组织学诊断由组织病理学顾问做出：结果：在 430 例子宫内膜活检中，第 1 组有 222 例（51.6%），第 2 组有 208 例（48.4%）。第二组有 12 例（5.7%）发现恶性病变，而第一组只有 4 例（1.8%）：两个年龄组最常见的子宫内膜病变都是子宫内膜息肉。与育龄期妇女相比，恶性病变更多见于绝经后妇女。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Pakistan Medical Association Medicine-General Medicine

CiteScore

1.10

自引率

11.10%

发文量

983

审稿时长

3-6 weeks

期刊介绍： Primarily being a medical journal, JPMA publishes scholarly research focusing on the various fields in the areas of health and medical education. It publishes original research describing recent advances in health particularly clinical studies, clinical trials, assessments of pathogens of diagnostic importance, medical genetics and epidemiological studies. Review articles highlighting importance of various issues in the domain of public health, drug research and medical education are also accepted. As a leading journal of South Asia, JPMA remains cognizant of the recent advances in the rapidly growing fields of biomedical sciences, it invites and encourages scholars to write short reviews and invited editorials on the emerging issues. We particularly aim to promote health standards of developing countries by encouraging manuscript submissions on issues affecting the public health and health delivery services.