Psychotic Experiences and Risk of Suicidal Thoughts and Behaviors: A Systematic Review and Meta-Analysis of Longitudinal Population Studies.

IF 5.3 1区医学 Q1 PSYCHIATRY

Schizophrenia Bulletin Pub Date : 2024-11-16 DOI:10.1093/schbul/sbae197

Kirstie O'Hare, Kubra Fadiloglu, Ulla Lång, Colm Healy, Mary Cannon, Jordan DeVylder, Ian Kelleher

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引用次数: 0

Abstract

Background and hypothesis: Since a prior systematic review and meta-analysis reported an association between psychotic experiences (PEs) and suicidal thoughts and behaviors, a large number of new studies have been published on the topic, including several novel studies on the association between PEs and transition from suicidal ideation to attempt.

Study design: Two authors independently searched PubMed, Embase, CINAHL, and PsycINFO databases from inception until July 2023, conducted data extraction, and assessed study quality using the Newcastle-Ottawa Quality Assessment Scale. Random-effects models were used to calculate pooled odds ratios (ORs) for the association of PEs and subsequent suicide ideation, suicide attempts, suicide death, and transition from suicidal ideation to attempt, first for the total population, and second stratified by age group. Secondary analyses assessed the mediating role of co-occurring psychopathology.

Study results: Twenty studies from 18 different samples (n = 81,861) were identified. Individuals who reported PEs had increased odds of subsequent suicidal ideation (k = 12, OR = 1.90, 95% CI = 1.65-2.19), suicide attempt (k = 13, OR = 2.95, 95% CI = 2.21-3.94), transition from suicidal ideation to suicide attempt (k = 3, OR = 2.83, 95% CI = 1.60-4.99), and suicide death (k = 1, OR = 4.39, 95% CI = 1.63-11.80). This heightened risk was stable across childhood, adolescence, and adulthood. PEs predicted suicide attempts over and above co-occurring psychopathology (k = 8, OR = 2.85, 95% CI = 2.06-3.95).

Conclusions: Individuals reporting PEs are at increased risk of all types of suicidal thoughts and behaviors. In addition, PEs are particularly important risk markers for future suicidal behaviors, including in individuals already reporting suicidal ideation. This risk is in excess of what is explained by co-occurring psychopathology.

查看原文本刊更多论文

精神病经历与自杀想法和行为的风险：纵向人群研究的系统回顾和元分析》（A Systematic Review and Meta-Analysis of Longitudinal Population Studies）。

背景与假设：自从之前的一项系统综述和荟萃分析报告了精神病性经验（PEs）与自杀想法和行为之间的关联之后，又有大量关于该主题的新研究发表，其中包括几项关于PEs与从自杀想法到自杀未遂之间的关联的新研究：两位作者独立检索了从开始到 2023 年 7 月的 PubMed、Embase、CINAHL 和 PsycINFO 数据库，进行了数据提取，并使用纽卡斯尔-渥太华质量评估量表评估了研究质量。研究人员使用随机效应模型计算了PE与随后的自杀意念、自杀未遂、自杀死亡以及从自杀意念到自杀未遂的转变之间的相关性的集合几率比（ORs），首先计算了总人口的几率比，其次按年龄组进行了分层。二次分析评估了并发精神病理学的中介作用：确定了来自 18 个不同样本（n = 81,861 人）的 20 项研究。报告了 PE 的个体随后出现自杀意念（k = 12，OR = 1.90，95% CI = 1.65-2.19）、自杀未遂（k = 13，OR = 2.95，95% CI = 2.21-3.94）、从自杀意念转变为自杀未遂（k = 3，OR = 2.83，95% CI = 1.60-4.99）和自杀死亡（k = 1，OR = 4.39，95% CI = 1.63-11.80）的几率增加。这种风险的增加在儿童期、青春期和成年期都是稳定的。PE对自杀未遂的预测高于并发精神病理学（k = 8，OR = 2.85，95% CI = 2.06-3.95）：结论：报告有 PEs 的人出现各种自杀想法和行为的风险都会增加。此外，PE 还是未来自杀行为的重要风险标志，包括已报告有自杀想法的人。这种风险超出了并发精神病理学所能解释的范围。

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来源期刊

Schizophrenia Bulletin 医学-精神病学

CiteScore

11.40

自引率

6.10%

发文量

163

审稿时长

4-8 weeks

期刊介绍： Schizophrenia Bulletin seeks to review recent developments and empirically based hypotheses regarding the etiology and treatment of schizophrenia. We view the field as broad and deep, and will publish new knowledge ranging from the molecular basis to social and cultural factors. We will give new emphasis to translational reports which simultaneously highlight basic neurobiological mechanisms and clinical manifestations. Some of the Bulletin content is invited as special features or manuscripts organized as a theme by special guest editors. Most pages of the Bulletin are devoted to unsolicited manuscripts of high quality that report original data or where we can provide a special venue for a major study or workshop report. Supplement issues are sometimes provided for manuscripts reporting from a recent conference.