Effects of Type II Diabetes on upper extremity muscle characteristics in older adults

IF 2.5 4区医学 Q3 NEUROSCIENCES

Neuroscience Letters Pub Date : 2024-11-15 DOI:10.1016/j.neulet.2024.138039

Lauren I. Gulley Cox , Nicholas Dias , Chuan Zhang , Yingchun Zhang , Stacey L. Gorniak

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Abstract

With one in every four older adults living with T2D and one in every two older adults meeting the criteria for prediabetes, neuromuscular changes due to T2D are likely to impact functional activities in this population. Limited work in evaluating motor unit number and size across muscles in the upper extremity in persons with Type II Diabetes (T2D) exists, mostly due to the traditional belief bias that the upper extremity is relatively spared in T2D as compared to the lower extremities. The purpose of the current study was to evaluate motor unit number and size (using electrophysiological motor unit number index (MUNIX) and motor unit size index (MUSIX)) across the upper extremity in older adults with T2D (n = 13) as compared to healthy age- and sex-matched controls (n = 12). Persons with T2D presented with more motor units and larger motor unit sizes (p < 0.05) as compared to age- and sex-matched control participants. These changes were not dependent upon muscle location within a limb, indicating systemic neuromuscular changes associated with T2D. These group effects were clarified when health state covariates (e.g., blood pressure) were accounted for. Findings are consistent with emerging data that show altered neuromuscular characteristics with health state considerations in persons with T2D.

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II 型糖尿病对老年人上肢肌肉特征的影响。

每四个老年人中就有一个患有 T2D，每两个老年人中就有一个符合糖尿病前期的标准，T2D 引起的神经肌肉变化很可能会影响这一人群的功能活动。评估 II 型糖尿病（T2D）患者上肢肌肉运动单位数量和大小的工作十分有限，这主要是由于传统观念的偏差，即与下肢相比，T2D 患者的上肢肌肉相对较少损伤。本研究的目的是评估患有 T2D 的老年人（13 人）与年龄和性别匹配的健康对照组（12 人）的上肢运动单位数量和大小（使用电生理运动单位数量指数 (MUNIX) 和运动单位大小指数 (MUSIX)）。T2D患者的运动单位数量更多，运动单位尺寸更大（p

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来源期刊

Neuroscience Letters 医学-神经科学

CiteScore

5.20

自引率

0.00%

发文量

408

审稿时长

50 days

期刊介绍： Neuroscience Letters is devoted to the rapid publication of short, high-quality papers of interest to the broad community of neuroscientists. Only papers which will make a significant addition to the literature in the field will be published. Papers in all areas of neuroscience - molecular, cellular, developmental, systems, behavioral and cognitive, as well as computational - will be considered for publication. Submission of laboratory investigations that shed light on disease mechanisms is encouraged. Special Issues, edited by Guest Editors to cover new and rapidly-moving areas, will include invited mini-reviews. Occasional mini-reviews in especially timely areas will be considered for publication, without invitation, outside of Special Issues; these un-solicited mini-reviews can be submitted without invitation but must be of very high quality. Clinical studies will also be published if they provide new information about organization or actions of the nervous system, or provide new insights into the neurobiology of disease. NSL does not publish case reports.