Development and validation of the placenta-QUS model for the detection of placenta-mediated diseases using quantitative ultrasound measurements: An Ex Vivo proof-of-concept study

IF 3 2区医学 Q2 DEVELOPMENTAL BIOLOGY

Placenta Pub Date : 2024-11-10 DOI:10.1016/j.placenta.2024.11.004

Farah Deeba , Ricky Hu , Victoria Lessoway , Jefferson Terry , Denise Pugash , Chantal Mayer , Jennifer Hutcheon , Robert Rohling

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引用次数: 0

Abstract

Introduction

Placenta-mediated diseases are associated with structural changes in the placenta. Quantitative Ultrasound (QUS) imaging measures the acoustic properties of the tissue, which are correlated to the underlying tissue structure. We aimed to develop and validate a diagnostic prediction model using QUS measurements for pre-eclampsia (PE) and small-for-gestational-age (SGA) fetuses/neonates.

Methods

For this prospective case-control study, placentas were collected from a group of women who delivered via cesarean section at BC Women's Hospital, Vancouver, Canada. Ultrasound data were collected and processed to compute three QUS parameters, namely, attenuation coefficient estimate (ACE), integrated backscatter coefficient (IBC), and effective scatterer diameter (ESD) from the placentas. We developed a logistic regression model using QUS parameters as predictors. The primary outcome was the occurrence of SGA and PE.

Results

The dataset consisted of 47 placentas, of which 25 placentas were complicated by SGA/PE. The final placenta-QUS model included quadratic and interaction terms of ACE, IBC, and ESD parameters. The placenta-QUS model was well-calibrated, with a calibration slope of 0.99 (0.57–1.05) and a calibration intercept of 0.003 (−0.02 − 0.22). The model predicted the SGA/PE complicated pregnancies with an apparent Area Under the Receive Operating Characteristic Curve (AUROC) of 0.89 (95 % CI: 0.78–0.98). The optimism-adjusted AUROC was 0.88 (95 % CI: 0.78–0.98).

Discussion

A model for SGA and PE has been developed using QUS measures from the placenta ex vivo. The model showed promising performance in detecting SGA/PE. Future studies will be performed to assess the model performance using QUS measures in utero.

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开发和验证胎盘-QUS 模型，利用定量超声测量检测胎盘介导的疾病：一项体内概念验证研究。

简介胎盘介导的疾病与胎盘的结构变化有关。定量超声（QUS）成像测量组织的声学特性，这些特性与下层组织结构相关。我们的目的是利用 QUS 测量结果开发并验证一个诊断预测模型，用于预测子痫前期（PE）和小于妊娠年龄（SGA）胎儿/新生儿：在这项前瞻性病例对照研究中，收集了加拿大温哥华不列颠哥伦比亚省妇女医院剖宫产产妇的胎盘。我们收集并处理了超声数据，以计算胎盘的三个 QUS 参数，即衰减系数估计值 (ACE)、综合后向散射系数 (IBC) 和有效散射体直径 (ESD)。我们利用 QUS 参数作为预测因子，建立了一个逻辑回归模型。主要结果是发生 SGA 和 PE：数据集包括 47 个胎盘，其中 25 个胎盘并发 SGA/PE。最终的胎盘-QUS模型包括ACE、IBC和ESD参数的二次项和交互项。胎盘-QUS 模型校准良好，校准斜率为 0.99 (0.57-1.05)，校准截距为 0.003 (-0.02 - 0.22)。该模型预测 SGA/PE 并发症妊娠的表观接受操作特征曲线下面积（AUROC）为 0.89（95 % CI：0.78-0.98）。乐观调整后的 AUROC 为 0.88（95 % CI：0.78-0.98）：讨论：利用胎盘体外的 QUS 测量建立了一个 SGA 和 PE 模型。该模型在检测 SGA/PE 方面表现良好。未来的研究将利用宫内 QUS 测量来评估该模型的性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Placenta 医学-发育生物学

CiteScore

6.30

自引率

10.50%

发文量

391

审稿时长

78 days

期刊介绍： Placenta publishes high-quality original articles and invited topical reviews on all aspects of human and animal placentation, and the interactions between the mother, the placenta and fetal development. Topics covered include evolution, development, genetics and epigenetics, stem cells, metabolism, transport, immunology, pathology, pharmacology, cell and molecular biology, and developmental programming. The Editors welcome studies on implantation and the endometrium, comparative placentation, the uterine and umbilical circulations, the relationship between fetal and placental development, clinical aspects of altered placental development or function, the placental membranes, the influence of paternal factors on placental development or function, and the assessment of biomarkers of placental disorders.