Synergistic approach of ertapenem and flucloxacillin or cefazolin for addressing persistent methicillin susceptible Staphylococcus aureus bacteremia

IF 1.4 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology Pub Date : 2024-11-01 DOI:10.1016/j.ijmmb.2024.100755

Yamuna Devi Bakthavatchalam , Rajiv Karthik , Anand Ashok , Kamini Walia (Scientist G) , Harathi Ragothaman , Soniya Krishnamoorthy , Yuvasri Manokaran , Balaji Veeraraghavan

引用次数: 0

Abstract

In the present study, we determine the synergistic activity of ertapenem with cefazolin and flucloxacillin against type A beta-lactamase producing Methicillin susceptible Staphylococcus aureus isolate. In the time kill assay, at standard inoculum, ertapenem with cefazolin showed >1 log kill and ertapenem with flucloxacillin demonstrated >2 log kill. When tested at high inoculum, both combinations achieved >1 log kill at 1x MIC.

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用厄他培南和氟氯西林或头孢唑啉的协同作用来解决对甲氧西林敏感的金黄色葡萄球菌持续性菌血症。

在本研究中，我们确定了厄他培南与头孢唑啉和氟氯西林对产生甲氧西林敏感性金黄色葡萄球菌的 A 型β-内酰胺酶的协同活性。在时间杀灭试验中，在标准接种量下，厄他培南与头孢唑啉的杀灭率大于 1 log，厄他培南与氟氯西林的杀灭率大于 2 log。在高接种量下进行测试时，这两种组合在 1x MIC 时的杀灭率均大于 1 log。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Medical Microbiology IMMUNOLOGY-

CiteScore

2.20

自引率

0.00%

发文量

154

审稿时长

73 days

期刊介绍： Manuscripts of high standard in the form of original research, multicentric studies, meta analysis, are accepted. Current reports can be submitted as brief communications. Case reports must include review of current literature, clinical details, outcome and follow up. Letters to the editor must be a comment on or pertain to a manuscript already published in the IJMM or in relation to preliminary communication of a larger study. Review articles, Special Articles or Guest Editorials are accepted on invitation.