Regulation and functions of the DLC family of RhoGAP proteins: Implications for development and cancer

IF 4.4 2区生物学 Q2 CELL BIOLOGY

Cellular signalling Pub Date : 2024-11-15 DOI:10.1016/j.cellsig.2024.111505

Yannick Frey , Cristiana Lungu , Monilola A. Olayioye

{"title":"Regulation and functions of the DLC family of RhoGAP proteins: Implications for development and cancer","authors":"Yannick Frey , Cristiana Lungu , Monilola A. Olayioye","doi":"10.1016/j.cellsig.2024.111505","DOIUrl":null,"url":null,"abstract":"<div><div>The DLC (Deleted in Liver Cancer) family of RhoGAP (Rho GTPase-activating) proteins has been extensively studied since the identification of the first family member nearly 30 years ago. Rho GTPase signaling is essential for various cellular processes, including cytoskeletal dynamics, cell migration, and proliferation. Members of the DLC family are key regulators of this signaling pathway, with well-established roles in development and carcinogenesis. Here, we provide a comprehensive review of research into DLC regulation and cellular functions over the last three decades. In particular, we summarize control mechanisms of DLC gene expression at both the transcriptional and post-transcriptional level. Additionally, recent advances in understanding the post-translational regulation of DLC proteins that allow for tuning of protein activity and localization are highlighted. This detailed overview will serve as resource for future studies aimed at further elucidating the complex regulatory mechanisms of DLC family proteins and exploring their potential as targets for therapeutic applications.</div></div>","PeriodicalId":9902,"journal":{"name":"Cellular signalling","volume":"125 ","pages":"Article 111505"},"PeriodicalIF":4.4000,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cellular signalling","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0898656824004807","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The DLC (Deleted in Liver Cancer) family of RhoGAP (Rho GTPase-activating) proteins has been extensively studied since the identification of the first family member nearly 30 years ago. Rho GTPase signaling is essential for various cellular processes, including cytoskeletal dynamics, cell migration, and proliferation. Members of the DLC family are key regulators of this signaling pathway, with well-established roles in development and carcinogenesis. Here, we provide a comprehensive review of research into DLC regulation and cellular functions over the last three decades. In particular, we summarize control mechanisms of DLC gene expression at both the transcriptional and post-transcriptional level. Additionally, recent advances in understanding the post-translational regulation of DLC proteins that allow for tuning of protein activity and localization are highlighted. This detailed overview will serve as resource for future studies aimed at further elucidating the complex regulatory mechanisms of DLC family proteins and exploring their potential as targets for therapeutic applications.

查看原文本刊更多论文

RhoGAP 蛋白 DLC 家族的调控和功能：对发育和癌症的影响。

自近 30 年前第一个 RhoGAP（Rho GTPase-activating）家族成员被确认以来，人们对该家族进行了广泛的研究。Rho GTPase 信号转导对细胞的各种过程至关重要，包括细胞骨架动力学、细胞迁移和增殖。DLC 家族成员是这一信号通路的关键调控因子，在发育和癌变过程中的作用已得到证实。在此，我们全面回顾了过去三十年中有关 DLC 调控和细胞功能的研究。我们特别总结了 DLC 基因表达在转录和转录后水平的调控机制。此外，我们还重点介绍了在理解 DLC 蛋白翻译后调控方面的最新进展，这种调控可以调整蛋白质的活性和定位。这一详细概述将为今后的研究提供资源，旨在进一步阐明 DLC 家族蛋白的复杂调控机制，并探索其作为治疗应用靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cellular signalling 生物-细胞生物学

CiteScore

8.40

自引率

0.00%

发文量

250

审稿时长

27 days

期刊介绍： Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.