Identification of risk factors for necrotizing enterocolitis in twins: a case-control matching analysis of over ten-years' experience.

IF 2 3区医学 Q2 PEDIATRICS

BMC Pediatrics Pub Date : 2024-11-16 DOI:10.1186/s12887-024-05188-x

Pengjian Zou, Wenhai Fang, Lili Wu, Juan He, Huimin Xia, Wei Zhong, Qiuming He

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引用次数: 0

Abstract

Objective: The identification of risk factors is crucial for the clinical prevention and diagnosis of necrotizing enterocolitis (NEC). Monochorionic twins (MCT), due to the high genetic homogeneity, provided a valuable model for investigating the risk factors of various diseases. This study aimed to explore the risk factors for NEC using MCT.

Methods: A retrospective review was conducted on the medical records of monochorionic twins (MCT) treated at Guangzhou Women and Children's Medical Center from January 2012 to March 2023. We compared perinatal condition, feeding and preceding condition between MCT pairs with NEC (NEC MCT) and without NEC(No NEC MCT).Logistic regression analysis was utilized to identify independent risk factors.

Result: In 85 pairs of monochorionic twins (MCT), NEC occurred in one twin in 78.8% of cases, whereas both twins were affected in 21.2% of cases. In the final cohort of 60 pairs of MCT, several parameters were found to differ significantly between NEC MCT group and No NEC MCT group. Compared to No NEC MCT group, the incidence of umbilical cord abnormalities was significantly higher in the NEC MCT group (25% vs. 8.3%, P = 0.014). Meanwhile, NEC MCT group showed higher prevalence of SGA infants (48.3% vs. 21.7%, P = 0.002) and sFGR (38.3% vs. 6.7%, P = 0.000). Furthermore, TTTs (13.3% vs. 3.3%, P = 0.027) and septicemia (25% vs. 5%, P = 0.002) were more common in NEC MCT group. In a multivariable logistic regression model, sFGR (OR 6.81,95%CI 2.1-21.9, p = 0.001) was eventually output as an independent risk factor.

Conclusion: Non-genetic factors play a predominant role in the pathogenesis of NEC. Umbilical cord abnormalities, SGA, sFGR, TTTs and septicemia significantly increase the risk of NEC. sFGR is an independent risk factor of NEC.

查看原文本刊更多论文

双胞胎坏死性小肠结肠炎风险因素的识别：对十多年经验的病例对照匹配分析。

目的：确定风险因素对于临床预防和诊断坏死性小肠结肠炎（NEC）至关重要。单绒毛膜双胎（MCT）具有高度的遗传同质性，为研究各种疾病的风险因素提供了宝贵的模型。本研究旨在利用单绒毛膜双胎研究 NEC 的风险因素：方法：回顾性分析2012年1月至2023年3月在广州市妇女儿童医疗中心接受治疗的单绒毛膜双胎（MCT）的病历。我们比较了有NEC（NEC MCT）和无NEC（No NEC MCT）的MCT双胎的围产期状况、喂养情况和之前的状况，并利用逻辑回归分析找出独立的风险因素：结果：在85对单绒毛膜双胎（MCT）中，78.8%的病例中单胎发生NEC，21.2%的病例中双胎均发生NEC。在最终的 60 对 MCT 群体中，发现 NEC MCT 组与无 NEC MCT 组的几项参数存在显著差异。与无 NEC MCT 组相比，NEC MCT 组的脐带异常发生率明显更高（25% 对 8.3%，P = 0.014）。同时，NEC MCT 组的 SGA 婴儿（48.3% 对 21.7%，P = 0.002）和 sFGR（38.3% 对 6.7%，P = 0.000）发生率更高。此外，TTT（13.3% 对 3.3%，P = 0.027）和败血症（25% 对 5%，P = 0.002）在 NEC MCT 组中更为常见。在多变量逻辑回归模型中，sFGR（OR 6.81，95%CI 2.1-21.9，P = 0.001）最终成为独立的风险因素：结论：非遗传因素在 NEC 的发病机制中占主导地位。脐带异常、SGA、sFGR、TTTs 和败血症会显著增加 NEC 的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Pediatrics PEDIATRICS-

CiteScore

3.70

自引率

4.20%

发文量

683

审稿时长

3-8 weeks

期刊介绍： BMC Pediatrics is an open access journal publishing peer-reviewed research articles in all aspects of health care in neonates, children and adolescents, as well as related molecular genetics, pathophysiology, and epidemiology.