Development of an innovative reusable terahertz biosensor platform integrated graphene and all-silicon groove for detecting cancer cells in aqueous environments.

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta Pub Date : 2025-02-01 Epub Date: 2024-11-15 DOI:10.1016/j.talanta.2024.127214

Haiyun Yao, Lanju Liang, Zhaoqing Sun, Ziqun Wang, Xiaofei Hu, Zhenhua Li, Xin Yan, Maosheng Yang, Jianquan Yao

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引用次数: 0

Abstract

The label-free detection and analysis of cancer cells using portable biosensing devices is crucial and promising. In this study, a novel reusable biosensing platform with a microfluidic-like based on terahertz plasmonic metasurfaces utilizing graphene integrated with an all-silicon groove for detecting liquid live cancer cells was developed. The proposed biosensor platform stands out because it can differentiate between the concentrations of three types of cancer cells by monitoring changes in resonance intensity and phase difference. The minimum concentration for identification was reduced to as low as 5 × 10⁴ cells/mL. We effectively constructed two-dimensional optical intensity cards using continuous wavelet transforms, which presented a more accurate approach for the recognition and determination of the three types of cancer cells. Our proposed biosensors show great potential for the determination and recognition of label-free cancer cells in aqueous environments as alternatives to non-immune biosensing technology.

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开发可重复使用的创新型太赫兹生物传感器平台，集成石墨烯和全硅槽，用于检测水环境中的癌细胞。

利用便携式生物传感设备对癌细胞进行无标记检测和分析至关重要且前景广阔。本研究开发了一种新型可重复使用的生物传感平台，该平台基于利用石墨烯的太赫兹等离子体元表面与全硅沟槽集成的微流体，用于检测液态活癌细胞。所提出的生物传感器平台非常突出，因为它可以通过监测共振频率和相位差的变化来区分三种癌细胞的浓度。识别的最低浓度已降至 5 × 104 cells/mL。我们利用连续小波变换有效地构建了二维光学强度卡，为识别和确定三种癌细胞提供了更精确的方法。作为非免疫生物传感技术的替代品，我们提出的生物传感器在水环境中测定和识别无标记癌细胞方面显示出巨大的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.