Effect of Sexual Partnerships on Zika Virus Transmission in Virus-Endemic Region, Northeast Brazil

IF 7.2 2区医学 Q1 IMMUNOLOGY

Emerging Infectious Diseases Pub Date : 2024-11-15 DOI:10.3201/eid3012.231733

Tereza Magalhaes, Flávio Codeço Coelho, Wayner V. Souza, Isabelle F.T. Viana, Thomas Jaenisch, Ernesto T.A. Marques, Brian D. Foy, Cynthia Braga

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Abstract

The epidemiologic effects of Zika virus (ZIKV) sexual transmission in virus-endemic countries remain unclear. We conducted a 2-level, linear mixed-effects logistic regression analysis by using a recently acquired population-based ZIKV and chikungunya virus (CHIKV) serologic dataset obtained from persons residing in Northeast Brazil (n = 2,070 participants). We adjusted mathematical models for housing type and age of participants; the models indicated a significantly higher likelihood of ZIKV seropositivity among persons engaged in a sexual relationship within the same household (odds ratio 1.25 [95% CI 1.00–1.55]; p = 0.047), regardless of their partner’s ZIKV serostatus, and among participants with a ZIKV-seropositive sex partner within the same household (odds ratio 1.54 [95% CI 1.18–2.01]; p = 0.002). CHIKV was also modeled as a control; no sex-associated effects were observed for CHIKV serology. Inclusion of ZIKV sexual transmission in prevention and control strategies is urgently needed, particularly in ZIKV-endemic regions.

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性伴侣关系对巴西东北部病毒流行地区寨卡病毒传播的影响

寨卡病毒（ZIKV）在病毒流行国家的性传播对流行病学的影响尚不清楚。我们利用最近从巴西东北部居民（n = 2,070 名参与者）中获得的基于人群的寨卡病毒和基孔肯雅病毒（CHIKV）血清学数据集，进行了两级线性混合效应逻辑回归分析。我们根据参与者的住房类型和年龄对数学模型进行了调整；模型显示，在同一家庭中有性关系的人中，无论其伴侣的 ZIKV 血清状态如何，ZIKV 血清阳性的可能性都明显较高（几率比 1.25 [95% CI 1.00-1.55]；p = 0.047）；在同一家庭中有 ZIKV 血清阳性性伴侣的人中，ZIKV 血清阳性的可能性也明显较高（几率比 1.54 [95% CI 1.18-2.01]；p = 0.002）。还将 CHIKV 作为对照进行建模；未观察到 CHIKV 血清学与性相关的影响。将 ZIKV 性传播纳入预防和控制策略刻不容缓，尤其是在 ZIKV 流行地区。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.