Predicting Clinical Outcomes of SARS-CoV-2 Drug Efficacy with a High-Throughput Human Airway Microphysiological System (Adv. Biology 11/2024)

Abstract

SARS-CoV-2 Drug Efficacy

Rapid identification of effective therapeutics for emerging infectious diseases requires predictive preclinical drug screening tools that are operable at scale in high-containment laboratory environments. In article number 2300511 Ashley L. Gard, Christine R. Fisher, and co-workers at Draper used a high-throughput human airway microphysiological system, PREDICT96-ALI, to evaluate the efficacy of several SARS-CoV-2 interventions and distinguish ineffective lead compounds from clinically efficacious antivirals.