Study of Density, Sound Velocity, And Conductance of Levocetirizine in Aqueous Sodium Chloride at Variable Temperatures

Abstract

Levocetirizine (LC), an antihistaminic, was tested in aqueous solutions with NaCl for density, sound velocity, and conductance. Volumetric and compressibility properties of an electrolyte-containing aqueous drug solution were investigated by evaluating trends in certain parameters and studying solute–solvent interactions in the ternary system. To study the effect of drug concentration and temperature on system behavior, experiments were conducted at varying drug concentrations (0–0.10 mol. kg^–1), NaCl concentrations (0.05, 0.10, and 0.15 mol·kg^–1), and temperatures (298.15, 308.15, and 318.15 K). In aqueous solutions, both specific and nonspecific LC–electrolyte interactions stabilize the solution mixture. Conductance tests have shown that drug molecules in sodium chloride solutions at different concentrations alter their structure. Different studies have been used to elucidate aqueous electrolytic solution interactions. Studying these systems helps illuminate drug action mechanisms and electrolyte–drug chemistry.