Palladium-Catalyzed Electrochemical Iodination of 1-Arylpyridine N-Oxides

Abstract

The palladium-catalyzed C–H iodination of 1-arylpyridine N-oxides proceeded under electrochemical oxidation conditions using I₂ as an iodine source. The reaction of isoquinoline N-oxides possessing various para- or meta-substituted aryl groups at the 1-position proceeded to give the corresponding iodination products. Electron-donating groups on the aryl group facilitated the reaction to give relatively high yields of the product. The reaction was also found to be applicable to 2-aryl-3-picoline N-oxides.