Solubility of Perindopril l-Arginine in 10 Pure Solvents and 3 Binary Solvents from 278.15 to 323.15 K

Abstract

The solubility of Perindopril l-Arginine was measured in ten pure solvents (water, methanol, ethanol, methyl ethyl ketone, isopropyl acetate, ethyl acetate, isobutyl acetate, n-propyl acetate, methyl tert-butyl ether, and methylcyclohexane) as well as in three binary solvent mixtures (methyl tert-butyl ether-water, methyl tert-butyl ether-methanol, and methyl tert-butyl ether-ethanol). These measurements were conducted using isothermal methods of the dynamic method across a temperature range of 278.15 to 323.15 K at a pressure of 0.1 MPa. The solubility data in pure solvents were analyzed using the modified Apelblat equation, Yaws equation, and Van’t Hoff equation. For the binary solvent mixtures, the data were correlated by using the improved Apelblat equation, the CNIBS/R-K model, and the Apelblat–Jouyban–Acree model. The calculated results from these models showed high agreement with the experimental data, confirming the reliability of these models.