A Comprehensive Exploration of the Synergistic Relationship between DMSO and Peroxide in Organic Synthesis

IF 8.6 2区化学 Q1 Chemistry

Topics in Current Chemistry Pub Date : 2024-11-15 DOI:10.1007/s41061-024-00482-9

Sumit Kumar, Ashutosh Dey, Barnali Maiti, Soumyadip Das, Sai Deepak Pasuparthy, Kishor Padala

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引用次数: 0

Abstract

In the realm of organic synthesis, reagents can serve not only as solvents but also as synthons. Dimethyl sulfoxide (DMSO) is recognized for its efficiency in this dual capacity, enabling diverse chemical transformations. DMSO can generate various synthons, including methyl, methylene, methine, oxygen, and methyl sulfoxide, broadening the accessible compound repertoire. Activation of DMSO as a reagent relies heavily on synergies with secondary agents like peroxide, persulfate, or iodine. Recent years have witnessed a surge in innovative synthetic techniques harnessing the synergistic interplay of DMSO and peroxide, leading to environmentally friendly and cost-effective reactions with mild conditions. This review highlights the synergistic effects of DMSO and peroxides (up to 2023), detailing their activation mechanisms and the generation of various synthons, along with numerous reported derivatives. Although this topic has received considerable attention in recent years, there are numerous discrepancies and a plethora of possibilities yet to be explored. We anticipate that this review will significantly support researchers in advancing their innovations to a greater extent in the future.

Graphical Abstract

This review accentuates the synergistic effects of DMSO and peroxides like potassium persulfate (K₂S₂O₈), sodium persulfate (Na₂S₂O₈), ammonium persulfate ((NH₄)₂S₂O₈), hydrogen peroxide (H₂O₂), and tertbutyl hydroperoxide (TBHP), as well as Oxone. It highlights their collaborative role in generating diverse synthons and elucidates the mechanisms of activation.

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有机合成中二甲基亚砜与过氧化物协同作用的全面探索。

在有机合成领域，试剂不仅可以用作溶剂，还可以用作合成物。二甲基亚砜（DMSO）因其高效的双重功能而备受认可，可实现多种化学转化。二甲基亚砜可以生成各种合成物，包括甲基、亚甲基、亚甲基、氧和甲基亚砜，从而扩大了可利用的化合物范围。作为一种试剂，二甲基亚砜的活化在很大程度上依赖于与过氧化物、过硫酸盐或碘等辅助剂的协同作用。近年来，利用二甲基亚砜和过氧化物协同作用的创新合成技术不断涌现，从而在温和的条件下实现了环境友好且经济高效的反应。本综述重点介绍了二甲基亚砜和过氧化物的协同效应（截至 2023 年），详细介绍了它们的活化机制、各种合成物的生成以及大量已报道的衍生物。尽管近年来这一主题受到了广泛关注，但仍有许多差异和大量可能性有待探索。我们希望这篇综述能为研究人员在未来更大程度上推进创新提供重要支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Topics in Current Chemistry 化学-化学综合

CiteScore

11.70

自引率

1.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.