Improving the processability and mechanical strength of self-hardening robocasted hydroxyapatite scaffolds with silane coupling agents

IF 3.3 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-11-09 DOI:10.1016/j.jmbbm.2024.106792

Piotr Pańtak , Joanna P. Czechowska , Adelia Kashimbetova , Ladislav Čelko , Edgar B. Montufar , Łukasz Wójcik , Aneta Zima

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引用次数: 0

Abstract

Bone cements are the subject of intensive research, primarily due to their versatility and the increasing importance for personalized medicine. In this study, novel hybrid self-setting scaffolds, based on calcium phosphates and natural polymers, were fabricated using the robocasting technique. Additionally, the influence of two different silane coupling agents, tetraethyl orthosilicate (TEOS) and 3-glycidoxypropyltrimethoxysilane (GPTMS), on the physicochemical and biological properties of the obtained materials was thoroughly investigated. The chemical and phase compositions (XRF, XRD, FTIR), setting process, rheological properties, mechanical strength, microstructure (SEM), and chemical stability in vitro were comprehensively examined. The use of silane coupling agents improved compressive strength of the scaffolds from 5.20 to 9.26 MPa. The incorporation of citrus pectin into the liquid phase of the materials, along with the use of a hybrid hydroxyapatite-chitosan powder, not only facilitated the development of printable pastes suitable for robocasting but also enhanced the physicochemical properties of the robocasted scaffolds. The results presented in this study underscore the beneficial influence of silane coupling agents on the characteristics of calcium phosphate-based bone scaffolds. Developed robocasted scaffolds hold great potential for applications in the field of bone tissue engineering and personalized medicine. Further in vitro and in vivo studies are necessary to validate their suitability for clinical applications.

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用硅烷偶联剂改善自硬性机器人浇注羟基磷灰石支架的加工性能和机械强度。

骨水泥是深入研究的主题，这主要是由于其多功能性和对个性化医疗的日益重要性。在这项研究中，我们使用机械铸造技术制造了基于磷酸钙和天然聚合物的新型混合自凝支架。此外，还深入研究了两种不同硅烷偶联剂--正硅酸四乙酯（TEOS）和 3-缩水甘油氧丙基三甲氧基硅烷（GPTMS）--对所获材料理化和生物特性的影响。对材料的化学成分和相组成（XRF、XRD、傅立叶变换红外光谱）、凝固过程、流变特性、机械强度、微观结构（扫描电镜）和体外化学稳定性进行了全面研究。硅烷偶联剂的使用将支架的抗压强度从 5.20 兆帕提高到 9.26 兆帕。在材料液相中加入柑橘果胶以及使用羟基磷灰石-壳聚糖混合粉末，不仅促进了适合机器人浇注的可印刷浆料的开发，还提高了机器人浇注支架的理化性能。本研究的结果凸显了硅烷偶联剂对磷酸钙基骨支架特性的有利影响。开发的机器人铸造支架在骨组织工程和个性化医疗领域具有巨大的应用潜力。要验证其是否适合临床应用，还需要进一步的体外和体内研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Mechanical Behavior of Biomedical Materials 工程技术-材料科学：生物材料

CiteScore

7.20

自引率

7.70%

发文量

505

审稿时长

46 days

期刊介绍： The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials. The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.