Cost-effectiveness of faecal microbiota transplantation compared with vancomycin monotherapy for early Clostridioides difficile infection: economic evaluation alongside a randomised controlled trial.

IF 3.9 3区医学 Q1 INFECTIOUS DISEASES

Journal of Hospital Infection Pub Date : 2024-11-13 DOI:10.1016/j.jhin.2024.11.003

Camilla R Birch, Sara E Paaske, Morten B Jensen, Simon M D Baunwall, Lars H Ehlers, Christian L Hvas

引用次数: 0

Abstract

For Clostridioides difficile infection (CDI), faecal microbiota transplantation (FMT) is currently recommended for patients with three or more CDI episodes. A recent randomised controlled trial (RCT) show that FMT may be considered early, defined as intervention during the first or second CDI episode. Compared with standard care for first or second CDI, patients randomised to FMT had €1,645 lower hospital costs over 26 weeks owing to fewer admissions and hospital contacts and less medication use.

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粪便微生物群移植与万古霉素单药治疗早期艰难梭菌感染的成本效益比较：随机对照试验的经济评估。

对于艰难梭菌感染（CDI），目前建议对 CDI 发作三次或三次以上的患者进行粪便微生物群移植（FMT）。最近的一项随机对照试验（RCT）表明，可以考虑尽早进行 FMT，即在 CDI 首次或第二次发作时进行干预。与针对首次或第二次 CDI 的标准治疗相比，随机接受 FMT 治疗的患者在 26 周内的住院费用降低了 1645 欧元，原因是入院次数和医院接触次数减少，用药次数减少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Hospital Infection 医学-传染病学

CiteScore

12.70

自引率

5.80%

发文量

271

审稿时长

19 days

期刊介绍： The Journal of Hospital Infection is the editorially independent scientific publication of the Healthcare Infection Society. The aim of the Journal is to publish high quality research and information relating to infection prevention and control that is relevant to an international audience. The Journal welcomes submissions that relate to all aspects of infection prevention and control in healthcare settings. This includes submissions that: provide new insight into the epidemiology, surveillance, or prevention and control of healthcare-associated infections and antimicrobial resistance in healthcare settings; provide new insight into cleaning, disinfection and decontamination; provide new insight into the design of healthcare premises; describe novel aspects of outbreaks of infection; throw light on techniques for effective antimicrobial stewardship; describe novel techniques (laboratory-based or point of care) for the detection of infection or antimicrobial resistance in the healthcare setting, particularly if these can be used to facilitate infection prevention and control; improve understanding of the motivations of safe healthcare behaviour, or describe techniques for achieving behavioural and cultural change; improve understanding of the use of IT systems in infection surveillance and prevention and control.