[Preoperative protective preparation of the nasal mucosa of rhinological patients].

Abstract

To reduce the inflammatory reaction that occurs in the nasal mucosa after surgical interventions, it seems promising to develop methods of preventive preparation of the epithelium to the effects of damaging factors in the preoperative period.

Objective: To evaluate the effectiveness of the protective effect of sodium deoxyribonuclease solution on the nasal mucosa in the preoperative period in rhinological patients.

Material and methods: 71 patients were examined after septoplasty with vasotomy of the lower nasal concha for curvature of the nasal septum and vasomotor rhinitis. Patients were divided into two groups: patients of group 1 (n=36) did not undergo protective preoperative preparation; patients of group 2 (n=35) were locally prescribed 0.25% sodium deoxyribonuclease solution as protective therapy. All patients underwent cytological examination of nasal secretions using smear prints at the initial treatment, before surgery, on the 5th, 10th, 21st, 30th, 42nd and 60th days of the postoperative period.

Results: The use of sodium deoxyribonuclease solution in the preoperative period led to statistically significant cytoprotective, anti-inflammatory, reparative and immunostimulating effects compared with the control group. There was a more pronounced and rapid restoration of the cellular composition of the mucous membrane, a decrease in the indices of destruction and cytolysis of cells compared with preoperative indicators.

Conclusion: The necessity and effectiveness of preoperative protective preparation of the nasal mucosa in rhinological patients is confirmed by the identified positive therapeutic effects.