Gene-environment interactions in the influence of maternal education on adolescent neurodevelopment using ABCD study

IF 11.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2024-11-15 DOI:10.1126/sciadv.adp3751

Runye Shi, Xiao Chang, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot17,, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Nathalie Holz, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Xiaolei Lin, Jianfeng Feng, IMAGEN Consortium

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Abstract

Maternal education was strongly correlated with adolescent brain morphology, cognitive performances, and mental health. However, the molecular basis for the effects of maternal education on the structural neurodevelopment remains unknown. Here, we conducted gene-environment–wide interaction study using the Adolescent Brain Cognitive Development cohort. Seven genomic loci with significant gene-environment interactions (G×E) on regional gray matter volumes were identified, with enriched biological functions related to metabolic process, inflammatory process, and synaptic plasticity. Additionally, genetic overlapping results with behavioral and disease-related phenotypes indicated shared biological mechanism between maternal education modified neurodevelopment and related behavioral traits. Finally, by decomposing the multidimensional components of maternal education, we found that socioeconomic status, rather than family environment, played a more important role in modifying the genetic effects on neurodevelopment. In summary, our study provided analytical evidence for G×E effects regarding adolescent neurodevelopment and explored potential biological mechanisms as well as social mechanisms through which maternal education could modify the genetic effects on regional brain development.

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利用 ABCD 研究分析母亲教育对青少年神经发育影响中的基因-环境相互作用。

母亲的教育程度与青少年的大脑形态、认知能力和心理健康密切相关。然而，母亲教育对神经结构发育影响的分子基础仍然未知。在此，我们利用青少年大脑认知发展队列开展了全基因环境交互作用研究。研究发现了七个基因组位点对区域灰质体积具有显著的基因-环境交互作用（G×E），其生物功能与代谢过程、炎症过程和突触可塑性有关。此外，基因与行为和疾病相关表型的重叠结果表明，母亲教育改变神经发育和相关行为特征之间存在共同的生物学机制。最后，通过分解母亲教育的多维成分，我们发现在改变遗传对神经发育的影响方面，社会经济地位比家庭环境发挥着更重要的作用。总之，我们的研究为青少年神经发育的 G×E 效应提供了分析证据，并探索了母亲教育可改变遗传对区域大脑发育影响的潜在生物机制和社会机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.