Insights into cancer characteristics among SARS-CoV-2 infected hospitalized patients: a comprehensive analysis from the National Clinical Registry for COVID-19.

IF 2.7 3区医学 Q3 ONCOLOGY

Journal of Cancer Research and Clinical Oncology Pub Date : 2024-11-15 DOI:10.1007/s00432-024-05966-1

Soumyadip Chatterji, Alka Turuk, Parijat Das, Sanjay Bhattacharya, Sudipta Mukherjee, Pralay Shankar Ghosh, Argha Chatterjee, Aparna Mukerjee, Gunjan Kumar, Aanchal Satija, Kripa Josten, Ashish Bhalla, Pankaj Malhotra, Sourin Bhuniya, Arunansu Talukdar, Soumitra Ghosh, Sanjeev Misra, Pankaj Bhardwaj, Subhranga Chatterjee, Geetha R Menon, Vishal Deo, Vishnu Vardhan Rao

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引用次数: 0

Abstract

Purpose: Cancer outcome is dependent on multiple predetermining factors including cancer, type of cancer and its related factors. This study aims to investigate the association between COVID-19 & cancer/cancer types, focusing on risk of in-hospital mortality within 30 days of hospitalization of COVID-19 patients with cancer.

Materials and methods: We did a registry (National Clinical Registry for COVID-19) based retrospective observational study including 51,544 patients, of whom 976 were patients with cancer, admitted with COVID-19 between August 2020 and August 2023 across 42 hospitals of India.

Results: Out of 51,544 patients, 976 (1.8%) had cancer. Hematological malignancies made up 15.06% (147 cases), while solid cancers accounted for 29.5% (288 cases), with genitourinary (18.4%, 80 cases), gastrointestinal (15.2%, 49 cases), and lung cancers (10.1%, 34 cases) being the most common. Solid cancers had the highest in-hospital mortality rate at 25%. Survival analysis showed that cancer-related hazards were highest at admission but decreased to levels comparable with other morbidities within nine to ten days. For each cancer type, the hazard was significantly elevated compared to that of the cancer-free (Other Comorbidities and No Comorbiditiy) groups during the initial period of hospitalization. The use of Remdesivir, steroids, and anticoagulants reduced mortality risk, and prior COVID-19 vaccination was protective against mortality across all cancer types.

Conclusion: This study shows that both cancer in general and specific cancer types significantly increase the risk of severe outcomes among SARS-CoV-2-infected patients, especially immediately after hospitalization. The findings highlight the need for close monitoring and personalized interventions for COVID-19 patients with cancer for at least 10 days post-hospitalization, with a more specific high-risk period ranging from 7 to 18 days depending on the type of cancer.

查看原文本刊更多论文

洞察SARS-CoV-2感染住院患者的癌症特征：来自COVID-19国家临床登记处的综合分析。

目的：癌症的预后取决于多种决定因素，包括癌症、癌症类型及其相关因素。本研究旨在调查 COVID-19 与癌症/癌症类型之间的关联，重点关注 COVID-19 癌症患者住院 30 天内的院内死亡风险：我们进行了一项基于登记（COVID-19 国家临床登记）的回顾性观察研究，研究对象包括 2020 年 8 月至 2023 年 8 月期间印度 42 家医院收治的 51,544 名 COVID-19 患者，其中 976 名为癌症患者：51,544名患者中，976人（1.8%）患有癌症。血液恶性肿瘤占 15.06%（147 例），实体癌占 29.5%（288 例），其中最常见的是泌尿生殖系统癌症（18.4%，80 例）、胃肠道癌症（15.2%，49 例）和肺癌（10.1%，34 例）。实体癌的院内死亡率最高，为 25%。存活率分析表明，癌症相关危害在入院时最高，但在九到十天内会降低到与其他疾病相当的水平。在住院初期，与无癌症组（其他并发症组和无并发症组）相比，每种癌症类型的危险性都明显升高。使用雷米替韦、类固醇和抗凝血剂可降低死亡风险，而之前接种的COVID-19疫苗对所有癌症类型的死亡率都有保护作用：本研究表明，一般癌症和特定癌症类型会显著增加 SARS-CoV-2 感染者出现严重后果的风险，尤其是在住院后不久。研究结果突出表明，有必要对 COVID-19 癌症患者在住院后至少 10 天内进行密切监测并采取个性化干预措施，根据癌症类型的不同，更具体的高风险期为 7 至 18 天。

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来源期刊

Journal of Cancer Research and Clinical Oncology 医学-肿瘤学

CiteScore

4.00

自引率

2.80%

发文量

577

审稿时长

2 months

期刊介绍： The "Journal of Cancer Research and Clinical Oncology" publishes significant and up-to-date articles within the fields of experimental and clinical oncology. The journal, which is chiefly devoted to Original papers, also includes Reviews as well as Editorials and Guest editorials on current, controversial topics. The section Letters to the editors provides a forum for a rapid exchange of comments and information concerning previously published papers and topics of current interest. Meeting reports provide current information on the latest results presented at important congresses. The following fields are covered: carcinogenesis - etiology, mechanisms; molecular biology; recent developments in tumor therapy; general diagnosis; laboratory diagnosis; diagnostic and experimental pathology; oncologic surgery; and epidemiology.