Cell inspired delivery system equipped with natural membrane structures in applications for rescuing ischemic stroke.

IF 10.5 1区医学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Journal of Controlled Release Pub Date : 2024-11-13 DOI:10.1016/j.jconrel.2024.11.013

Anran Zhu, Yingyu Jiang, Longxiang Pan, Jiale Li, Yao Huang, Minghui Shi, Liuqing Di, Lei Wang, Ruoning Wang

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引用次数: 0

Abstract

Ischemic stroke (IS), accounting for 87 % of stroke incidences, constitutes a paramount health challenge owing to neurological impairments and irreversible tissue damage arising from cerebral ischemia. Chief among therapeutic obstacles are the restrictive penetration of the blood-brain barrier (BBB) and insufficient targeting precision, hindering the accumulation of drugs in ischemic brain areas. Motivated by the remarkable capabilities of natural membrane-based delivery vehicles in achieving targeted delivery and traversing the BBB, thanks to their biocompatible architecture and bioactive components, numerous membrane-engineered systems such as cells, cell membranes and extracellular vesicles have emerged as promising platforms to augment IS treatment efficacy with the help of nanotechnology. This review consolidates the primary pathological manifestations following IS, elucidates the unique functionalities of natural membrane drug delivery systems (DDSs) with nanotechnology, as well as delineates the structural characteristics of various natural membranes alongside rational design strategies employed. The review illuminates both the potential and challenges encountered when employing natural membrane DDSs in IS drug therapy, offering fresh perspectives and insights for devising efficacious and practical delivery systems tailored to IS intervention.

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配备天然膜结构的细胞启发输送系统在抢救缺血性中风中的应用。

缺血性脑卒中（IS）占脑卒中发病率的 87%，由于脑缺血导致的神经功能损伤和不可逆的组织损伤，它已成为一项重大的健康挑战。治疗的主要障碍是血脑屏障（BBB）的限制性穿透和靶向精确性不足，阻碍了药物在缺血脑区的蓄积。天然膜基递送载体凭借其生物相容性结构和生物活性成分，在实现靶向递送和穿越 BBB 方面具有卓越的能力，受此激励，细胞、细胞膜和细胞外囊泡等众多膜工程系统已成为借助纳米技术提高 IS 治疗效果的前景广阔的平台。本综述综述了 IS 后的主要病理表现，阐明了天然膜给药系统（DDS）与纳米技术的独特功能，并描述了各种天然膜的结构特征以及所采用的合理设计策略。综述阐明了在 IS 药物治疗中使用天然膜给药系统的潜力和所遇到的挑战，为设计适合 IS 干预的高效实用给药系统提供了新的视角和见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Controlled Release 医学-化学综合

CiteScore

18.50

自引率

5.60%

发文量

700

审稿时长

39 days

期刊介绍： The Journal of Controlled Release (JCR) proudly serves as the Official Journal of the Controlled Release Society and the Japan Society of Drug Delivery System. Dedicated to the broad field of delivery science and technology, JCR publishes high-quality research articles covering drug delivery systems and all facets of formulations. This includes the physicochemical and biological properties of drugs, design and characterization of dosage forms, release mechanisms, in vivo testing, and formulation research and development across pharmaceutical, diagnostic, agricultural, environmental, cosmetic, and food industries. Priority is given to manuscripts that contribute to the fundamental understanding of principles or demonstrate the advantages of novel technologies in terms of safety and efficacy over current clinical standards. JCR strives to be a leading platform for advancements in delivery science and technology.