{"title":"Homogeneity analysis of medicine tablets by laser induced breakdown spectroscopy combined with multivariate methods","authors":"Amir Hossein Farhadian , Maedeh Mollaei","doi":"10.1016/j.ejpb.2024.114579","DOIUrl":null,"url":null,"abstract":"<div><div>Pharmaceutical tablets need to have a homogenous chemical structure, especially in cases where the patient may divide the tablet in half prior to consumption. This work aims to demonstrate the viability of using laser induced breakdown spectroscopy (LIBS) for analyzing the homogeneity and determining the chemical composition of losartan potassium tablets. This was accomplished by obtaining the spectra of 10 tablet points in 30 successive laser pulses, which revealed four main peaks (C, H, N, and O) as well as a high concentration of calcium and potassium in the core tablets and titanium in the coating—all of which are excellent analytical objectives for LIBS. It is possible to say that the generated plasma meets the minimum requirement for local thermodynamic equilibrium because the physical parameters of the plasma, including temperature (T) and electronic density (N<sub>e</sub>), were calculated throughout the Boltzmann plot and Stark broadened line, respectively, and the McWhirter criterion was met. In addition, T and N<sub>e</sub> changes have been used for homogeneity analysis. Different peak comparisons cannot provide us with further data because the major structural components are similar, making it challenging to differentiate between them. So relative standard deviation (RSD) and principal component analysis (PCA) were used to comprise the whole spectra, which showed that the homogeneity of the tablet’s core is better than that of the coating and is acceptable.</div></div>","PeriodicalId":12024,"journal":{"name":"European Journal of Pharmaceutics and Biopharmaceutics","volume":"205 ","pages":"Article 114579"},"PeriodicalIF":4.4000,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Pharmaceutics and Biopharmaceutics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0939641124004053","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Pharmaceutical tablets need to have a homogenous chemical structure, especially in cases where the patient may divide the tablet in half prior to consumption. This work aims to demonstrate the viability of using laser induced breakdown spectroscopy (LIBS) for analyzing the homogeneity and determining the chemical composition of losartan potassium tablets. This was accomplished by obtaining the spectra of 10 tablet points in 30 successive laser pulses, which revealed four main peaks (C, H, N, and O) as well as a high concentration of calcium and potassium in the core tablets and titanium in the coating—all of which are excellent analytical objectives for LIBS. It is possible to say that the generated plasma meets the minimum requirement for local thermodynamic equilibrium because the physical parameters of the plasma, including temperature (T) and electronic density (Ne), were calculated throughout the Boltzmann plot and Stark broadened line, respectively, and the McWhirter criterion was met. In addition, T and Ne changes have been used for homogeneity analysis. Different peak comparisons cannot provide us with further data because the major structural components are similar, making it challenging to differentiate between them. So relative standard deviation (RSD) and principal component analysis (PCA) were used to comprise the whole spectra, which showed that the homogeneity of the tablet’s core is better than that of the coating and is acceptable.
期刊介绍:
The European Journal of Pharmaceutics and Biopharmaceutics provides a medium for the publication of novel, innovative and hypothesis-driven research from the areas of Pharmaceutics and Biopharmaceutics.
Topics covered include for example:
Design and development of drug delivery systems for pharmaceuticals and biopharmaceuticals (small molecules, proteins, nucleic acids)
Aspects of manufacturing process design
Biomedical aspects of drug product design
Strategies and formulations for controlled drug transport across biological barriers
Physicochemical aspects of drug product development
Novel excipients for drug product design
Drug delivery and controlled release systems for systemic and local applications
Nanomaterials for therapeutic and diagnostic purposes
Advanced therapy medicinal products
Medical devices supporting a distinct pharmacological effect.