Assessing spatial memory using the Brown Location Test: Lateralizing seizures in a presurgical cohort of patients with temporal lobe epilepsy

IF 2.3 3区 医学 Q2 BEHAVIORAL SCIENCES
Nicholas W.G. Murray , Madison E. Choma , Ada Lo , Zoe Thayer , Petra L. Graham , Evelyn E. Harvey
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引用次数: 0

Abstract

Objective

Whilst the dominant temporal lobe has a well-established role in memory, the functions of its nondominant counterpart remain enigmatic. We compared the lateralizing ability of a promising spatial memory task (Brown Location Test, BLT) to other commonly used verbal and visual memory tasks in a sample of patients with unilateral temporal lobe epilepsy (TLE).

Methods

Neuropsychological data from 48 TLE patients (right n = 28 and left n = 20) were compared on several verbal and nonverbal memory tasks. Univariate logistic regression analyses were used to examine the relationship between test scores and the odds of being categorised as right or left TLE, while multivariable logistic regression and decision tree analyses were used to establish the optimal combination of cognitive measures for lateralizing the epileptogenic zone (EZ).

Results

Relative to normative expectations, the right TLE group was specifically impaired on BLT measures, whereas the left TLE group was impaired on verbal and nonverbal memory tasks. The combination of BLT Delayed Recall and Delayed Recall on the Rey Auditory Verbal Learning Task (RAVLT) was identified as optimal for correctly predicting EZ laterality (AUC = 0.79). These two variables were also optimal predictors in the decision tree analysis, correctly predicting 79% of the overall sample (AUC = 0.83).

Conclusions

Our findings support the BLT as a measure of right temporal lobe function. They demonstrate its superior sensitivity compared to another commonly used nonverbal memory test (i.e., Visual Reproduction; VR) and highlight the added lateralizing value of combining both verbal and nonverbal memory measures in the neuropsychological evaluation of epilepsy surgery candidates.
使用布朗定位测试评估空间记忆:颞叶癫痫患者手术前发作的侧向性。
目的:虽然优势颞叶在记忆中的作用已得到证实,但其非优势颞叶的功能仍是个谜。我们以单侧颞叶癫痫(TLE)患者为样本,比较了有前途的空间记忆任务(布朗定位测试,BLT)与其他常用的言语和视觉记忆任务的侧化能力:比较了 48 名 TLE 患者(右侧 28 人,左侧 20 人)在多项言语和非言语记忆任务中的神经心理学数据。采用单变量逻辑回归分析来研究测试得分与被归类为右侧或左侧TLE的几率之间的关系,同时采用多变量逻辑回归和决策树分析来确定致痫区(EZ)侧向化的最佳认知测量组合:结果:相对于常模预期,右侧TLE组在BLT测量上特别受损,而左侧TLE组在言语和非言语记忆任务上受损。BLT延迟回忆和Rey听觉言语学习任务(RAVLT)延迟回忆的组合被认为是正确预测EZ偏侧的最佳方法(AUC = 0.79)。在决策树分析中,这两个变量也是最佳预测变量,能正确预测79%的总体样本(AUC = 0.83):我们的研究结果支持将 BLT 作为衡量右颞叶功能的指标。结论:我们的研究结果支持BLT作为右颞叶功能的测量指标,与另一种常用的非言语记忆测试(即视觉再现;VR)相比,BLT具有更高的灵敏度,并强调了在对癫痫手术候选者进行神经心理评估时将言语和非言语记忆测量相结合所带来的侧化价值。
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来源期刊
Epilepsy & Behavior
Epilepsy & Behavior 医学-行为科学
CiteScore
5.40
自引率
15.40%
发文量
385
审稿时长
43 days
期刊介绍: Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy. Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging. From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.
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