Conflict during learning reconfigures the neural representation of positive valence and approach behavior.

IF 8.1 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Current Biology Pub Date : 2024-12-02 Epub Date: 2024-11-14 DOI:10.1016/j.cub.2024.10.024
Laura Molina-García, Susana Colinas-Fischer, Sergio Benavides-Laconcha, Lucy Lin, Emma Clark, Neythen J Treloar, Blanca García-Minaur-Ortíz, Milly Butts, Chris P Barnes, Arantza Barrios
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引用次数: 0

Abstract

Punishing and rewarding experiences can change the valence of sensory stimuli and guide animal behavior in opposite directions, resulting in avoidance or approach. Often, however, a stimulus is encountered with both positive and negative experiences. How is such conflicting information represented in the brain and resolved into a behavioral decision? We address this question by dissecting a circuit for sexual conditioning in C. elegans. In this learning paradigm, an odor is conditioned with both a punishment (starvation) and a reward (mates), resulting in odor approach. We find that negative and positive experiences are both encoded by the neuropeptide pigment dispersing factor 1 (PDF-1) being released from, and acting on, different neurons. Each experience creates a distinct memory in the circuit for odor processing. This results in the sensorimotor representation of the odor being different in naive and sexually conditioned animals, despite both displaying approach. Our results reveal that the positive valence of a stimulus is not represented in the activity of any single neuron class but flexibly represented within the circuit according to the experiences and predictions associated with the stimulus.

学习过程中的冲突会重构积极情绪和接近行为的神经表征。
惩罚和奖励经历会改变感官刺激的价值,并引导动物行为向相反的方向发展,从而导致回避或接近。然而,通常情况下,一种刺激会同时带来积极和消极的体验。这种相互冲突的信息是如何在大脑中呈现并转化为行为决策的呢?我们通过解剖 elegans 的性调节回路来解决这个问题。在这种学习范式中,一种气味同时受到惩罚(饥饿)和奖励(交配),从而导致气味接近。我们发现,消极和积极的经历都是由神经肽色素分散因子1(PDF-1)编码的,它从不同的神经元释放并作用于不同的神经元。每种经历都会在气味处理回路中产生不同的记忆。这就导致在天真动物和性条件反射动物中,气味的感觉运动表征是不同的,尽管两者都显示出接近性。我们的研究结果表明,刺激的正价并不体现在任何一个神经元类别的活动中,而是根据与刺激相关的经验和预测在回路中灵活地体现出来。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Biology
Current Biology 生物-生化与分子生物学
CiteScore
11.80
自引率
2.20%
发文量
869
审稿时长
46 days
期刊介绍: Current Biology is a comprehensive journal that showcases original research in various disciplines of biology. It provides a platform for scientists to disseminate their groundbreaking findings and promotes interdisciplinary communication. The journal publishes articles of general interest, encompassing diverse fields of biology. Moreover, it offers accessible editorial pieces that are specifically designed to enlighten non-specialist readers.
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