Association Between Different Insulin Resistance Indices and Heart Failure in US Adults With Diabetes Mellitus

IF 1.1 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Annals of Noninvasive Electrocardiology Pub Date : 2024-11-15 DOI:10.1111/anec.70035

Lirong Chen, Lin Qian, Yongming Liu

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引用次数: 0

Abstract

Purpose

This study aims to scrutinize the association between various Insulin Resistance (IR) indices and heart failure (HF) risk in adult diabetics within the United States.

Methods

The National Health and Nutrition Examination Survey (NHANES) (2005–2018) dataset was used in this study. Weighted logistic regression analysis and restricted cubic spline were employed to ascertain the correlation between IR indices and the incidence of HF in diabetic patients. The predictive capability of the IR indices was evaluated using the Receiver Operating Characteristic curve.

Results

This study included a total of 2574 diabetic patients, out of which 209 (8.1%) were diagnosed with HF. After the adjustment of potential confounders, TyG-BMI (OR: 1.005, 95% CI: 1.002–1.009), TG/HDL-C (OR: 1.138, 95% CI: 1.024–1.265), and METS-IR index (OR: 1.035, 95% CI: 1.015–1.057) were significantly associated with HF risk. RCS curves revealed nonlinear dose–response relationship between TyG, TyG-BMI, TG/HDL-C, and the occurrence of HF in diabetic patients. Subgroup analyses showed that four IR indices were positively associated with the risk of HF in the elderly diabetic population. Unfortunately, all IR indices failed to improve the predictive performance of the underlying risk model for HF in diabetic patients.

Conclusion

Four IR markers may be important predictors of HF risk in diabetics.

Abstract Image

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美国成人糖尿病患者不同胰岛素抵抗指数与心力衰竭之间的关系。

目的：本研究旨在探讨美国成年糖尿病患者的各种胰岛素抵抗（IR）指数与心力衰竭（HF）风险之间的关联：本研究采用了美国国家健康与营养调查（NHANES）（2005-2018 年）数据集。采用加权逻辑回归分析和受限立方样条曲线来确定糖尿病患者红外指数与心房颤动发病率之间的相关性。使用受体工作特征曲线评估了IR指数的预测能力：本研究共纳入 2574 名糖尿病患者，其中 209 人（8.1%）被确诊为心房颤动。在调整潜在混杂因素后，TyG-BMI（OR：1.005，95% CI：1.002-1.009）、TG/HDL-C（OR：1.138，95% CI：1.024-1.265）和 METS-IR 指数（OR：1.035，95% CI：1.015-1.057）与心房颤动风险显著相关。RCS曲线显示，TyG、TyG-BMI、TG/HDL-C与糖尿病患者发生心房颤动之间存在非线性剂量-反应关系。亚组分析显示，在老年糖尿病人群中，四种IR指数与心房颤动风险呈正相关。遗憾的是，所有的IR指数都未能提高糖尿病患者心房颤动基本风险模型的预测性能：结论：四种红外标志物可能是糖尿病患者高血压风险的重要预测指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Noninvasive Electrocardiology 医学-心血管系统

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The ANNALS OF NONINVASIVE ELECTROCARDIOLOGY (A.N.E) is an online only journal that incorporates ongoing advances in the clinical application and technology of traditional and new ECG-based techniques in the diagnosis and treatment of cardiac patients. ANE is the first journal in an evolving subspecialty that incorporates ongoing advances in the clinical application and technology of traditional and new ECG-based techniques in the diagnosis and treatment of cardiac patients. The publication includes topics related to 12-lead, exercise and high-resolution electrocardiography, arrhythmias, ischemia, repolarization phenomena, heart rate variability, circadian rhythms, bioengineering technology, signal-averaged ECGs, T-wave alternans and automatic external defibrillation. ANE publishes peer-reviewed articles of interest to clinicians and researchers in the field of noninvasive electrocardiology. Original research, clinical studies, state-of-the-art reviews, case reports, technical notes, and letters to the editors will be published to meet future demands in this field.