Sensorable zwitterionic antibacterial hydrogel for wound electrostimulation therapy

IF 12.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Biomaterials Pub Date : 2024-11-09 DOI:10.1016/j.biomaterials.2024.122958

Jinghua Li , Meijun Chen , Shaowen Cheng , Shegan Gao , Jingming Zhai , Dongmei Yu , Jianping Wang , Jianbo Zhang , Kaiyong Cai

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引用次数: 0

Abstract

Wound healing process has always been a focal point of concern, with a plethora of hydrogel dressings available; however, their therapeutic efficacy remains a hindrance to wound closure. This article reports on a dual-network conductive system, PEDOT:PSS-co-PSBMA/XLG (PPSX) hydrogel dressing, Constructed using poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT: PSS) in combination with zwitterionic N, N-dimethyl-N-(2-methacryloyloxyethyl)-N- (3-sulfopropyl) ammonium betaine (SBMA) and nanoclay-synthesized lithium magnesium silicate (XLG). The hydrogel powder produced from it can absorb interfacial water within 30 s via physical interactions to spontaneously form hydrogels of arbitrary shapes. With a conductivity of 1.8 s/m, it can be utilized for developing flexible sensing bioelectronic devices to monitor human activities (facial expressions, blinking, swallowing, speaking, joint movements), as well as constructing electrodes for monitoring muscle movements and motorial intensity. More importantly, PPSX hydrogel effectively inhibits bacterial growth and promotes cell proliferation, thus facilitating wound healing and presenting extensive application prospects in the medical field.

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用于伤口电刺激疗法的可感应齐聚物抗菌水凝胶

伤口愈合过程一直是人们关注的焦点，水凝胶敷料层出不穷；然而，其治疗效果仍然是伤口愈合的障碍。本文报告了一种双网络导电系统--PEDOT:PSS-co-PSBMA/XLG（PPSX）水凝胶敷料，该敷料由聚（3,4-亚乙二氧基噻吩）:聚（苯乙烯磺酸）（PEDOT：PSS）与滋阴离子 N，N-二甲基-N-（2-甲基丙烯酰氧乙基）-N-（3-磺丙基）甜菜碱铵（SBMA）和纳米粘土合成的硅酸镁锂（XLG）结合制成。由其制成的水凝胶粉末可在 30 秒内通过物理相互作用吸收界面水，自发形成任意形状的水凝胶。它的电导率为 1.8 s/m，可用于开发监测人体活动（面部表情、眨眼、吞咽、说话、关节运动）的柔性传感生物电子设备，以及构建监测肌肉运动和运动强度的电极。更重要的是，PPSX 水凝胶能有效抑制细菌生长，促进细胞增殖，从而促进伤口愈合，在医疗领域具有广泛的应用前景。

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来源期刊

Biomaterials 工程技术-材料科学：生物材料

CiteScore

26.00

自引率

2.90%

发文量

565

审稿时长

46 days

期刊介绍： Biomaterials is an international journal covering the science and clinical application of biomaterials. A biomaterial is now defined as a substance that has been engineered to take a form which, alone or as part of a complex system, is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnostic procedure. It is the aim of the journal to provide a peer-reviewed forum for the publication of original papers and authoritative review and opinion papers dealing with the most important issues facing the use of biomaterials in clinical practice. The scope of the journal covers the wide range of physical, biological and chemical sciences that underpin the design of biomaterials and the clinical disciplines in which they are used. These sciences include polymer synthesis and characterization, drug and gene vector design, the biology of the host response, immunology and toxicology and self assembly at the nanoscale. Clinical applications include the therapies of medical technology and regenerative medicine in all clinical disciplines, and diagnostic systems that reply on innovative contrast and sensing agents. The journal is relevant to areas such as cancer diagnosis and therapy, implantable devices, drug delivery systems, gene vectors, bionanotechnology and tissue engineering.