Nano-enabled dynamically responsive living acellular hydrogels†

IF 12.2 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Materials Horizons Pub Date : 2024-10-25 DOI:10.1039/D4MH00922C

Roya Koshani, Sina Kheirabadi and Amir Sheikhi

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引用次数: 0

Abstract

As a key building block of mammalian tissues, extracellular matrices (ECMs) stiffen under shear deformation and undergo cell-imparted healing after damage, features that regulate cell fate, communication, and survival. The shear-stiffening behavior is attributed to semi-flexible biopolymeric ECM networks. Inspired by the mechanical behavior of ECMs, we develop acellular nanocomposite living hydrogels (LivGels), comprising network-forming biopolymers and anisotropic hairy nanoparticle linkers that mimic the dynamic mechanical properties of living counterparts. We show that a bifunctional dynamic linker nanoparticle (nLinker), bearing semi-flexible aldehyde- and carboxylate-modified cellulose chains attached to rigid cellulose nanocrystals converts bulk hydrogels to ECM-like analogues via ionic and dynamic covalent hydrazone bonds. The nLinker not only enables the manipulation of nonlinear mechanics and stiffness within the biological window, but also imparts self-healing to the LivGels. This work is a step forward in designing living acellular soft materials with complex dynamic properties using bio-based nanotechnology.

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纳米动态响应活细胞水凝胶。

作为哺乳动物组织的重要组成部分，细胞外基质（ECM）在剪切变形作用下会变硬，并在损伤后发生细胞诱导的愈合，这些特征调节着细胞的命运、交流和存活。剪切加固行为归因于半柔性生物高分子 ECM 网络。受 ECM 机械行为的启发，我们开发了细胞纳米复合活体水凝胶（LivGels），它由形成网络的生物聚合物和各向异性的毛状纳米粒子连接体组成，可模仿活体对应物的动态机械特性。我们的研究表明，一种双功能动态链接纳米粒子（nLinker）具有半柔性的醛和羧酸改性纤维素链，与刚性纤维素纳米晶体相连，通过离子键和动态共价腙键将块状水凝胶转化为类似 ECM 的类似物。nLinker 不仅能在生物窗口内操纵非线性力学和刚度，还能赋予 LivGels 自我修复功能。这项工作在利用生物纳米技术设计具有复杂动态特性的活细胞软材料方面向前迈出了一步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Horizons CHEMISTRY, MULTIDISCIPLINARY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

18.90

自引率

2.30%

发文量

306

审稿时长

1.3 months

期刊介绍： Materials Horizons is a leading journal in materials science that focuses on publishing exceptionally high-quality and innovative research. The journal prioritizes original research that introduces new concepts or ways of thinking, rather than solely reporting technological advancements. However, groundbreaking articles featuring record-breaking material performance may also be published. To be considered for publication, the work must be of significant interest to our community-spanning readership. Starting from 2021, all articles published in Materials Horizons will be indexed in MEDLINE©. The journal publishes various types of articles, including Communications, Reviews, Opinion pieces, Focus articles, and Comments. It serves as a core journal for researchers from academia, government, and industry across all areas of materials research. Materials Horizons is a Transformative Journal and compliant with Plan S. It has an impact factor of 13.3 and is indexed in MEDLINE.