Xanthone Synthesis through Catalysis: Exploring the Green Limits of Homogeneous and Heterogeneous Methods

Abstract

The transition from traditional stoichiometric methods to catalytic processes has significantly advanced the synthesis of xanthones, privileged structures with diverse biological activities. This review critically examines various homogeneous and heterogeneous catalytic methodologies, emphasising their efficiency, and adherence to green chemistry principles. Through comparative analysis of key metrics such as Reaction Mass Efficiency (RME), Process Mass Intensity (PMI), E‐factor, and Turnover Number (TON), we highlight the superior performance of heterogeneous catalysts, which demonstrate high reusability, selectivity, and minimal waste generation. The choice of solvent, a crucial factor in the environmental footprint of these processes, is also assessed, focusing on greener alternatives. The robust nature and economic viability of heterogeneous catalysts make them ideal for large‐scale applications, offering suitable solutions for more environmentally‐friendly xanthone production. Furthermore, the reduction in byproducts and the importance of catalyst purity in pharmaceutical applications are discussed, underscoring the relevance of these advancements in meeting the rigorous standards of the industry. This review provides valuable insights into the ongoing evolution of catalytic strategies in xanthone synthesis, driving future developments in medicinal chemistry and green chemistry.