Américo J. S. Alves, João A. D. Silvestre, Teresa M. V. D. Pinho e Melo
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引用次数: 0
Abstract
The Front Cover illustrates the development of continuous flow spirocyclization of 6-alkylidenepenicillanates leading to chiral spiro-β-lactams through phosphine-catalyzed [3+2] annulation of allenoates and 1,3-dipolar cycloaddition with diphenyldiazomethane. The continuous-flow synthesis of spirocyclopropanepenicillanates through thermal ring contraction of spiro-1-pyrazolinepenicillanates was also included in the study. The reported methodology is a more sustainable approach for the scale-up production of compounds with significant biological properties in high yields. More information can be found in the Research Article by T. M. V. D. Pinho e Melo and co-workers (DOI: 10.1002/ejoc.202400689).
封面展示了 6-亚烷基青霉烷酸酯的连续流螺环化技术的发展，该技术通过磷化氢催化异烯酸酯的[3+2]环化反应以及与二苯基二氮甲烷的 1,3-二极环加成反应生成手性螺-β-内酰胺。该研究还包括通过螺-1-吡唑啉青霉烷酸酯的热环收缩连续流合成螺环丙青霉烷酸酯。所报告的方法是一种更可持续的方法，可用于扩大高产率生产具有重要生物特性的化合物。更多信息，请参阅 T. M. V. 的研究文章。V.D.Pinho e Melo 及其合作者的研究文章中（DOI: 10.1002/ejoc.202400689）。
期刊介绍：
The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies.
The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry:
Liebigs Annalen
Bulletin des Sociétés Chimiques Belges
Bulletin de la Société Chimique de France
Gazzetta Chimica Italiana
Recueil des Travaux Chimiques des Pays-Bas
Anales de Química
Chimika Chronika
Revista Portuguesa de Química
ACH—Models in Chemistry
Polish Journal of Chemistry.
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