Molecular engineering of the Au25(SG)18 nanocluster at the single cluster level to brighten the NIR-II fluorescence

IF 5.8 3区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Nanoscale Pub Date : 2024-11-15 DOI:10.1039/d4nr03047h
Hailiang Zhang, Jing Wang, Wenxiu Han, Pei Jiang
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引用次数: 0

Abstract

Au25(SG)18 (SG: glutathione) nanoclusters, characterized by their atomically precise structures, exhibit near-infrared II (NIR-II) fluorescence emission and excellent biocompatibilit, making them highly promising for imaging applications. However, their comparatively low photoluminescence quantum yield (QY) in aqueous solutions limits their further development. In this study, taking advantage of the molecular-like property of the Au25(SG)18 nanocluster, we employ a Schiff base reaction to improve their NIR-II emission for the first time. The formation of a Schiff base chemical bond restricts intramolecular motion of surface ligands on the Au25(SG)18 nanocluster, reduces the nonradiative rate, and increases the radiative transition rate. Consequently, the luminescence quantum yield of PDA-Au25(SG)18 (PDA: 2,6-pyridinedicarboxaldehyde) nanoclusters is enhanced to 3.26%. Moreover, the reaction between amino and aldehyde groups occurs at the single cluster level, ensuring that these PDA-Au25(SG)18 nanoclusters remain discrete with an ultrasmall size of 2.6 nm, facilitating rapid excretion via the renal system and also showing excellent photostability and biocompatibility.
在单簇水平对 Au25(SG)18 纳米簇进行分子工程设计,以增亮近红外-II 荧光
Au25(SG)18(SG:谷胱甘肽)纳米团簇具有精确的原子结构,可发出近红外 II(NIR-II)荧光,并具有良好的生物相容性,因此在成像应用方面大有可为。然而,它们在水溶液中相对较低的光致发光量子产率(QY)限制了它们的进一步发展。在本研究中,我们利用 Au25(SG)18 纳米团簇的类分子特性,首次采用希夫碱反应来提高它们的近红外-II 发射率。希夫碱化学键的形成限制了 Au25(SG)18 纳米团簇表面配体的分子内运动,降低了非辐射率,提高了辐射转变率。因此,PDA-Au25(SG)18(PDA:2,6-吡啶二甲醛)纳米团簇的发光量子产率提高到了 3.26%。此外,氨基和醛基之间的反应发生在单个簇水平,确保了这些 PDA-Au25(SG)18 纳米簇保持离散,具有 2.6 纳米的超小尺寸,有利于通过肾脏系统快速排泄,同时还表现出优异的光稳定性和生物相容性。
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来源期刊
Nanoscale
Nanoscale CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTECHNOLOGY
CiteScore
12.10
自引率
3.00%
发文量
1628
审稿时长
1.6 months
期刊介绍: Nanoscale is a high-impact international journal, publishing high-quality research across nanoscience and nanotechnology. Nanoscale publishes a full mix of research articles on experimental and theoretical work, including reviews, communications, and full papers.Highly interdisciplinary, this journal appeals to scientists, researchers and professionals interested in nanoscience and nanotechnology, quantum materials and quantum technology, including the areas of physics, chemistry, biology, medicine, materials, energy/environment, information technology, detection science, healthcare and drug discovery, and electronics.
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