Valorizing shrimp shell chitosan: a versatile biomaterial for fabricating effective antibacterial and antioxidant silver nanoparticles

IF 2.3 4区材料科学 Q2 MATERIALS SCIENCE, CERAMICS

Journal of Sol-Gel Science and Technology Pub Date : 2024-10-07 DOI:10.1007/s10971-024-06578-4

Abdelatif Aouadi, Djamila Hamada Saoud, Abdelkrim Rebiai, Salah Eddine Laouini, Abdelhak Achouri, Abdelmalek Zaater, Fahad Alharthi, Abderrhmane Bouafia, Hamdi Ali Mohammed, Gamil Gamal Hasan, Johar Amin Ahmed Abdullah

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Abstract

A study was conducted to explore the potential of using chitosan (CS) derived from shrimp shells, a bioorganic waste product, as a reducing and capping agent in the synthesis of silver nanocomposites (Cs-Ag NC). The objective of the study was to develop a simpler, faster, and more environmentally friendly method for producing Cs-Ag NC. The synthesized Cs-Ag NC was characterized using UV-Vis spectroscopy, X-ray diffraction spectroscopy, Fourier transform infrared spectroscopy, and scanning electron microscopy. The findings revealed that the Cs-Ag NC exhibited a crystalline structure, was coated with CS components, and had a spherical shape with an average diameter of approximately 20 nm. Under optimal conditions, the synthesized Cs-Ag NC demonstrated significant free radical scavenging activity against 2-diphenyl-1-picrylhydrazyl (DPPH) with an IC50 value of 1.65 mg/mL, substantial free radical scavenging activity against 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) with an IC50 value of 2.8 mg/mL, and notable anti-inflammatory activity. Additionally, the Cs-Ag NC exhibited significant antibacterial activity against several pathogenic strains, including Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus. Based on these findings, the synthesized Cs-Ag NC possess promising potential as therapeutic drugs for antioxidant and antibacterial applications.

Graphical Abstract

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利用虾壳壳聚糖：制造有效抗菌和抗氧化银纳米粒子的多功能生物材料

本研究旨在探索使用从虾壳中提取的壳聚糖（CS）（一种生物有机废物）作为还原剂和封端剂合成银纳米复合材料（Cs-Ag NC）的潜力。这项研究的目的是开发一种更简单、更快速、更环保的方法来生产铯银纳米复合材料。使用紫外可见光谱、X 射线衍射光谱、傅立叶变换红外光谱和扫描电子显微镜对合成的铯银纳米复合材料进行了表征。研究结果表明，铯银 NC 具有晶体结构，表面包覆有 CS 成分，呈球形，平均直径约为 20 纳米。在最佳条件下，合成的 Cs-Ag NC 对 2-二苯基-1-苦基肼（DPPH）具有显著的自由基清除活性（IC50 值为 1.65 mg/mL），对 2,2'-偶氮-双（3-乙基苯并噻唑啉-6-磺酸）（ABTS）具有显著的自由基清除活性（IC50 值为 2.8 mg/mL），并具有明显的抗炎活性。此外，Cs-Ag NC 对包括绿脓杆菌、大肠杆菌和金黄色葡萄球菌在内的几种致病菌株具有显著的抗菌活性。基于这些发现，合成的铯银 NC 具有作为抗氧化和抗菌治疗药物的巨大潜力。

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来源期刊

Journal of Sol-Gel Science and Technology 工程技术-材料科学：硅酸盐

CiteScore

4.70

自引率

4.00%

发文量

280

审稿时长

2.1 months

期刊介绍： The primary objective of the Journal of Sol-Gel Science and Technology (JSST), the official journal of the International Sol-Gel Society, is to provide an international forum for the dissemination of scientific, technological, and general knowledge about materials processed by chemical nanotechnologies known as the "sol-gel" process. The materials of interest include gels, gel-derived glasses, ceramics in form of nano- and micro-powders, bulk, fibres, thin films and coatings as well as more recent materials such as hybrid organic-inorganic materials and composites. Such materials exhibit a wide range of optical, electronic, magnetic, chemical, environmental, and biomedical properties and functionalities. Methods for producing sol-gel-derived materials and the industrial uses of these materials are also of great interest.