Regioselective bromination of pyrrolo[1,2-a]quinoxalines†

Abstract

In this study, we report a novel and efficient method for the regioselective bromination of pyrrolo[1,2-a]quinoxalines using tetrabutylammonium tribromide (TBATB). This method exploits the mild nature of TBATB to obtain highly selective C3-brominated or C1, C3-dibrominated products in good yields. Notably, the reaction has a broad substrate applicability, and the C3-brominated product can be synthesized on a gram scale and can be further converted into structurally diverse pyrrolo[1,2-a]quinoxaline derivatives.