Episodic Coma in Lewy Body Disorders: An Observational Report.

IF 0.9 Q4 CLINICAL NEUROLOGY
Joseph H Friedman
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Abstract

Background: and Purpose: Episodes of unresponsiveness are one of several criteria used to diagnose dementia with Lewy bodies and are also seen in people with Parkinson's disease dementia. Patients examined during episodes of coma, whose evaluations found no other explanation than the neurological disorder, have not been described. This paper describes four cases, seen in the past two years. The objective is to bring this uncommon phenomenon to the attention of hospital based neurologists and to demonstrate that this may not be due to autonomic dysfunction.

Methods: These are brief case descriptions by medical personnel observing affected patients supplemented by family reports of similar episodes described on the internet.

Results: Four cases are described, all older men with either dementia with Lewy bodies or Parkinson's disease dementia, who had single, or multiple episodes of otherwise unexplained coma and were examined during a spell. IRB approval waived.

Conclusions: Episodic coma may occur in demented patients with an alpha-synucleinopathy and is the likely explanation when evaluations have found no other cause. This information will reassure the family and patient that this is the likely explanation but that spells may recur.

路易体失调症的发作性昏迷:观察报告
背景和目的:反应迟钝发作是诊断路易体痴呆症的几个标准之一,也见于帕金森病痴呆症患者。在昏迷发作期间接受检查的患者,其评估结果除神经紊乱外没有其他解释,这种情况尚未见报道。本文描述了过去两年中的四个病例。目的是让医院的神经科医生注意到这种不常见的现象,并证明这可能不是自律神经功能失调造成的:这些都是观察患者的医务人员对病例的简要描述,并以互联网上类似病例的家属报告作为补充:结果:本文描述了四个病例,均为患有路易体痴呆症或帕金森病痴呆症的老年男性患者,他们曾出现过一次或多次原因不明的昏迷,并在昏迷期间接受了检查。结论:结论:α-突触核蛋白病痴呆患者可能会出现发作性昏迷,当评估未发现其他原因时,发作性昏迷可能是一种解释。这些信息可以让家属和患者放心,这是可能的解释,但昏迷可能会再次发生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neurohospitalist
Neurohospitalist CLINICAL NEUROLOGY-
CiteScore
1.60
自引率
0.00%
发文量
108
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