The Fundamentals of Antiseizure Medications: A Through Z.

IF 5.8 2区 医学 Q1 CLINICAL NEUROLOGY
Timothy E Welty, Jeannine M Conway, Jacquelyn Bainbridge, Kristen Park, David G Vossler, Archana A Patel, Alica Goldman
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引用次数: 0

Abstract

Since bromides were first used in 1857 to treat epilepsy, numerous antiseizure medications (ASM) have been developed. Many of these are available for the treatment of epilepsy and status epilepticus today. With so many ASM available, questions arise as to whether all of these medications are needed and when should they be used. As precision medicine begins to play a larger role in determining targeted treatments for specific types of epilepsy, a complete understanding of various medications is needed. Additionally, access to several of these medications can be limited in the United States and are especially limited globally. All these factors can make proper selection of ASM challenging and difficult for clinicians. This review highlights important aspects of older and newer medications, developments in precision medicine for epilepsy, increasing understanding of effective treatments for status epileptics, and a global perspective on ASM availability.

抗癫痫药物的基础知识:从 A 到 Z。
自 1857 年首次使用溴化物治疗癫痫以来,已开发出许多抗癫痫药物 (ASM)。如今,其中许多药物都可用于治疗癫痫和癫痫状态。面对如此众多的抗癫痫药物,人们不禁要问,是否需要所有这些药物,以及何时应该使用这些药物。随着精准医学开始在确定特定类型癫痫的靶向治疗中发挥更大作用,我们需要全面了解各种药物。此外,在美国,获得其中几种药物的途径可能有限,在全球范围内尤其如此。所有这些因素都会给临床医生正确选择 ASM 带来挑战和困难。本综述重点介绍了老药和新药的重要方面、癫痫精准医学的发展、对癫痫状态患者有效治疗方法的进一步了解以及从全球角度看 ASM 的可用性。
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来源期刊
Epilepsy Currents
Epilepsy Currents CLINICAL NEUROLOGY-
CiteScore
2.40
自引率
5.60%
发文量
88
审稿时长
>12 weeks
期刊介绍: Epilepsy Currents is an open access, bi-monthly current-awareness journal providing reviews, commentaries and abstracts from the world’s literature on the research and treatment of epilepsy. Epilepsy Currents surveys and comments on all important research and developments in a format that is easy to read and reference. Each issue is divided into two main sections: Basic Science and Clinical Science. An outstanding Editorial Board reviews the literature and assigns topics and articles to world experts for comment. In addition, the Editors commission authoritative review articles on important subjects.
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