An investigation of multimodal predictors of adolescent alcohol initiation

IF 3.9 2区医学 Q1 PSYCHIATRY

Drug and alcohol dependence Pub Date : 2024-10-31 DOI:10.1016/j.drugalcdep.2024.112491

Andrew Moore , Ben Lewis , Amanda Elton , Lindsay M. Squeglia , Sara Jo Nixon

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引用次数: 0

Abstract

Background

Early alcohol initiation is associated with negative, alcohol-related outcomes. While previous work identifies numerous risk factors for early use, the relative contributions of known predictors remains understudied. The current project addresses this gap by 1) prospectively predicting early alcohol initiation using measures of inhibition control, reward sensitivity, and contextual risk factors and 2) interrogating the relative importance of each domain.

Method

This study leverages multimodal data from substance-naïve youth enrolled in the Adolescent Brain Cognitive Development (ABCD) Study® (n=11,694). Early initiation was defined as consuming a full standard drink containing alcohol prior to age 16. Propensity scores were used to match alcohol initiators (n=348) with demographically similar non-initiators at a 1:2 ratio (n=696). Independent logistic regressions were conducted for each domain followed by additive, hierarchical models.

Results

The model of contextual factors (pseudo-R²=0.086, AUC=0.67) outperformed inhibition control (pseudo-R²=0.021, AUC=0.58) and reward sensitivity measures (pseudo-R²=0.020, AUC=0.59). The hierarchical model containing all measures (pseudo-R²=0.106, AUC=0.69) did not significantly improve the model of contextual factors alone (p>0.05). Examples of significant predictors (p<0.05) include externalizing behaviors, number of substances known, and non-religious alcohol sipping.

Conclusion

Contextual risk factors were the strongest predictors of early alcohol use; however, more work is needed to understand the causal nature of this relationship. Measures of inhibition control and reward sensitivity were not adequate in distinguishing initiators from non-initiators. These findings add to a body of evidence that contextual factors play a major role in alcohol initiation while highlighting specific predictor variables that could inform youth alcohol prevention.

查看原文本刊更多论文

青少年开始酗酒的多模式预测调查。

背景：过早开始饮酒与酒精相关的负面结果有关。虽然以往的研究发现了许多早期饮酒的风险因素，但对已知预测因素的相对贡献研究仍然不足。目前的项目通过以下方法填补了这一空白：1）使用抑制控制、奖赏敏感性和情境风险因素的测量方法对早期酗酒进行前瞻性预测；2）询问每个领域的相对重要性：本研究利用了参加青少年大脑认知发展研究（ABCD）®（人数=11,694）的未接触过药物的青少年的多模态数据。过早开始饮酒被定义为在 16 岁之前饮用了全量含酒精的标准饮料。采用倾向分数将饮酒初始者（人数=348）与人口统计学上相似的非初始者（人数=696）按1:2的比例进行匹配。对每个领域进行独立的逻辑回归，然后采用加法分层模型：结果：情境因素模型（pseudo-R2=0.086，AUC=0.67）优于抑制控制模型（pseudo-R2=0.021，AUC=0.58）和奖赏敏感性测量模型（pseudo-R2=0.020，AUC=0.59）。包含所有测量指标的分层模型（pseudo-R2=0.106，AUC=0.69）并没有显著改善单独的情境因素模型（p>0.05）。重要预测因素示例（p 结论：情境风险因素是早期饮酒的最强预测因素；然而，要了解这种关系的因果性质，还需要做更多的工作。对抑制控制和奖赏敏感性的测量不足以区分酗酒者和非酗酒者。这些研究结果补充了大量证据，证明环境因素在酒精启蒙中起着重要作用，同时强调了可为青少年酒精预防提供参考的特定预测变量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug and alcohol dependence 医学-精神病学

CiteScore

7.40

自引率

7.10%

发文量

409

审稿时长

41 days

期刊介绍： Drug and Alcohol Dependence is an international journal devoted to publishing original research, scholarly reviews, commentaries, and policy analyses in the area of drug, alcohol and tobacco use and dependence. Articles range from studies of the chemistry of substances of abuse, their actions at molecular and cellular sites, in vitro and in vivo investigations of their biochemical, pharmacological and behavioural actions, laboratory-based and clinical research in humans, substance abuse treatment and prevention research, and studies employing methods from epidemiology, sociology, and economics.