Incorporation of cerium oxide nanoparticles into the micro-arc oxidation layer promotes bone formation and achieves structural integrity in magnesium orthopedic implants

IF 9.4 1区 医学 Q1 ENGINEERING, BIOMEDICAL
Guan-Lin Wu , Chin-En Yen , Wei-Chien Hsu , Ming-Long Yeh
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引用次数: 0

Abstract

Biodegradable metals offer significant advantages by reducing the need for additional surgeries following bone fixation. These materials, with their optimal mechanical and degradable properties, also mitigate stress-shielding effects while promoting biological processes essential for healing. This study investigated the in vitro and in vivo biocompatibility of ZK60 magnesium alloy coated with a micro-arc oxidative layer incorporated with cerium oxide nanoparticles in orthopedic implants. The results demonstrated that the magnesium substrate undergoes gradual degradation, effectively eliminating long-term inflammation during bone formation. The micro-arc oxidative coating forms a dense ceramic layer, acting as a protective barrier that reduces corrosion rates and enhances the biocompatibility of the magnesium substrate. The incorporation of cerium oxide nanoparticles improves the tribological properties of the coating, refining degradation patterns and improving osteogenic characteristics. Furthermore, cerium oxide nanoparticles enhance bone reconstruction by facilitating appropriate interconnections between newly formed bone and native bone tissue. Consequently, cerium oxide nanoparticles contribute to favorable biosafety outcomes and exceptional bone remodeling capabilities by supporting bone healing and sustaining a prolonged degradation process, ultimately achieving dynamic equilibrium in bone formation.

Statement of significance

This study comprehensively examined the incorporation of cerium oxide nanoparticles into biodegradable magnesium through a micro-arc oxidative process for use in orthopedic implants. This study conducted a comprehensive analysis involving material characterization, biodegradability testing, in vitro osteogenesis assays, and in vivo implantation, highlighting the potential benefits of the distinctive properties of cerium oxide nanoparticles. This research emphasizes the ability of cerium oxide nanoparticles to enhance the biodegradability of magnesium and facilitate remarkable bone regeneration, suggesting promising advantages for additive materials in orthopedic implants.

Abstract Image

在微弧氧化层中加入氧化铈纳米粒子可促进骨形成,并实现镁骨科植入物的结构完整性。
生物可降解金属具有显著优势,可减少骨骼固定后的额外手术需求。这些材料具有最佳的机械和可降解特性,还能减轻应力屏蔽效应,同时促进愈合所必需的生物过程。本研究调查了ZK60镁合金的体外和体内生物相容性,该材料在骨科植入物上涂覆了一层含有氧化铈纳米颗粒的微弧氧化层。结果表明,镁基质会逐渐降解,有效消除了骨形成过程中的长期炎症。微弧氧化涂层形成了致密的陶瓷层,起到了保护屏障的作用,降低了腐蚀率,增强了镁基底的生物相容性。纳米氧化铈颗粒的加入改善了涂层的摩擦学特性,细化了降解模式,提高了成骨特性。此外,纳米氧化铈颗粒还能促进新形成的骨与原生骨组织之间的适当互连,从而加强骨重建。因此,纳米氧化铈粒子通过支持骨愈合和维持长时间的降解过程,最终实现骨形成的动态平衡,有助于实现良好的生物安全结果和卓越的骨重塑能力。意义说明:本研究全面考察了通过微弧氧化工艺将纳米氧化铈颗粒掺入可生物降解的镁中,用于骨科植入物的情况。该研究进行了全面的分析,包括材料表征、生物降解性测试、体外成骨试验和体内植入,突出强调了氧化铈纳米粒子独特性能的潜在优势。这项研究强调了氧化铈纳米粒子增强镁的生物降解性和促进显著骨再生的能力,为骨科植入物添加材料带来了希望。
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来源期刊
Acta Biomaterialia
Acta Biomaterialia 工程技术-材料科学:生物材料
CiteScore
16.80
自引率
3.10%
发文量
776
审稿时长
30 days
期刊介绍: Acta Biomaterialia is a monthly peer-reviewed scientific journal published by Elsevier. The journal was established in January 2005. The editor-in-chief is W.R. Wagner (University of Pittsburgh). The journal covers research in biomaterials science, including the interrelationship of biomaterial structure and function from macroscale to nanoscale. Topical coverage includes biomedical and biocompatible materials.
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